Diazine-Amide Compounds for Targeted Insecticidal Efficacy
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current pesticides, particularly those for controlling insects and arthropods, lack efficacy and specificity, leading to environmental and health concerns.
Innovation Solution
Development of novel pesticidally active diazine-amide compounds, specifically those of formula I, which include various substituents and agrochemically acceptable salts, stereoisomers, and N-oxides, to enhance insecticidal activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current pesticides are used to control insects and arthropods, then pest control function is provided, but efficacy and specificity are insufficient leading to environmental and health concerns
Solution Approach 1:
The patent applies parameter changes by developing a new chemical compound structure (diazine-amide with specific heteroaryl substituents) that fundamentally alters the molecular parameters of pesticides. This structural modification enables enhanced insecticidal activity through improved binding affinity to target enzymes (acetylcholinesterase) while reducing non-specific toxicity to non-target organisms, thereby resolving the contradiction between efficacy and environmental safety
Solution Approach 2:
The invention employs composite material principles by creating complex heteroaryl-diazine-amide structures that combine multiple functional moieties (heteroaryl rings, diazine core, amide linkers) into a single molecular entity. This composite structure allows simultaneous optimization of pest control activity, selectivity, and environmental compatibility that cannot be achieved with simpler pesticide molecules
2Reliability
If novel diazine-amide compounds are developed to enhance insecticidal activity, then pesticidal efficacy is improved, but compound structure complexity increases
Solution Approach 1:
The patent applies segmentation by dividing the pesticide molecule into distinct functional segments: a heteroaryl group (providing metabolic stability and target binding), a diazine-amide core (providing acetylcholinesterase inhibition), and substitutable positions for optimizing specificity. This modular segmentation allows systematic optimization of insecticidal activity while managing molecular complexity through defined structural domains
Data Source
AI summary
Compounds of formula I (l) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.