Diclofenac Sodium Adhesive Patch for Non-Lumbar Lumbago Relief

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Solution Overview

Problem

Existing patches for treating lumbago applied to regions other than the lumbar region face challenges due to distribution by blood circulation, hepatic metabolism, and renal excretion, making it unclear if increased medical agent content is effective.

Innovation Solution

A patch containing 0.70 to 1.50 mg of diclofenac sodium per cm² of application area, applied to regions like the chest, abdominal, dorsal, brachial, or femoral regions, effectively relieves lumbago by using a specific adhesive composition and application method.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If patches containing medical agents at high concentrations are applied to sites other than the affected region, then the distribution to other tissues is affected by blood circulation, hepatic metabolism, and renal excretion, but it is unclear whether simply increasing the content of medical agents will achieve the desired effect of relieving lumbago

Engineering Contradiction:

Improvecontent of medical agentVSAvoideffectiveness in relieving lumbago

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent optimizes the concentration parameter of diclofenac sodium in the adhesive layer, establishing that 0.70 to 1.50 mg per cm² of application area is the effective range for relieving lumbago when applied to non-lumbar regions. This parameter optimization resolves the contradiction by identifying the precise concentration level that achieves therapeutic effectiveness without unnecessary increase in substance content

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent applies the adhesive layer containing diclofenac sodium to body regions other than the lumbar region (such as chest, abdominal, dorsal, brachial, or femoral regions), effectively copying the application approach to alternative sites. This strategy maintains effectiveness by demonstrating that the optimized concentration formulation works reliably when applied to non-affected regions, bypassing the need for direct lumbar application

Inventive Principle:

Principle #26Copying

2Quantity of substance

If the lumbar region is targeted for patch application, then the tissue concentration of the medical agent is increased topically, but it is difficult for patients to reach the affected region by their own hands

Engineering Contradiction:

Improvetissue concentration of medical agentVSAvoidease of application

Core Design Contradiction:

Quantity of substanceVSEase of operation

Solution Approach 1:

Inventive Principle:

Principle #26Copying

Solution Approach 2:

The patent uses blood circulation as an intermediary mechanism to transport diclofenac sodium from the application site (non-lumbar region) to the lumbar region and other tissues. This intermediary approach allows the medical agent to reach the affected area indirectly, eliminating the need for direct patient application to the lumbar region while maintaining therapeutic effectiveness

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The patch achieves effective relief of lumbago when applied to non-lumbar regions, maintaining a desired plasma concentration of diclofenac sodium for sustained pain relief.

Implementation Method 1

A patch is a type of percutaneous absorption formulation manufactured by spreading out a plaster containing a medical agent on a backing

Methodology Applied

Scientific EffectPercutaneous absorption: Absorption (physical)

Data Source

PatentUS20250288537A1Diclofenac sodium-containing adhesive patch

Publication Date: 2025.09.18 HISAMITSU PHARM CO INC

AI summary

The present invention provides a patch for relieving lumbago, the patch comprising a backing and an adhesive layer laminated on the backing, wherein the adhesive layer comprises an adhesive base and 0.70 to 1.50 mg of diclofenac sodium per cm2 of application area, and the patch is used by applying the patch once a day to the chest region, the abdominal region, the dorsal region, the brachial region, or the femoral region of a human.