Dielectrophoretic Analysis Device Using Frequency-Modulated AC Voltage

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Solution Overview

Problem

The existing characteristic analysis method for dielectric particles is complicated and does not allow for easy separation of particles after analysis, particularly in measuring the crossover frequency of dielectrophoretic forces.

Innovation Solution

An analysis device and separation device that utilize a flow channel system with frequency-modulated AC voltage and imaging to determine the crossover frequency of dielectrophoretic forces on particles, allowing for easy analysis and subsequent separation of dielectric particles based on the analyzed frequency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If particles are positioned between fine microelectrodes for crossover frequency measurement, then measurement precision is improved, but device complexity and operation difficulty increase

Engineering Contradiction:
Improvecrossover frequency measurement precisionVSAvoidmicroelectrode positioning complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The device is divided into two independent modules: an analysis device for crossover frequency measurement and a separation device for particle separation. The analysis device contains simplified electrodes suitable for measurement, while the separation device contains the fine microelectrodes for separation. This segmentation allows each module to be optimized for its specific function without the complexity of integrating both functions into a single system.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The analysis device is designed to perform multiple functions: it can measure crossover frequency and also serve as a preliminary separation unit. By making the analysis device multi-functional, the system reduces the need for complex positioning of fine microelectrodes while maintaining measurement precision and enabling subsequent separation operations.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Measurement precision

If particles are positioned between fine microelectrodes for analysis, then analysis accuracy is improved, but ease of operation deteriorates

Engineering Contradiction:
Improvecrossover frequency analysis accuracyVSAvoidparticle positioning ease
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The system separates the analysis function from the separation function into distinct devices. The analysis device uses simplified electrode structures that are easier to operate while maintaining measurement accuracy. The fine microelectrodes are confined to the separation device, eliminating the need for complex positioning operations during the analysis phase.

Inventive Principle:
Principle #1Segmentation

3Measurement precision

If frequency-modulated AC voltage is applied to analyze particle movement, then crossover frequency detection is improved, but device complexity increases

Engineering Contradiction:
Improvecrossover frequency detection precisionVSAvoidfrequency modulation system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system replaces complex mechanical positioning systems with an electrical field-based approach. By applying frequency-modulated AC voltage to the electrodes, particles are manipulated and analyzed through electrical forces rather than mechanical positioning, simplifying the overall device structure while maintaining measurement precision.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

4Productivity

If particles are separated after analysis, then productivity is improved, but device complexity increases

Engineering Contradiction:
Improveparticle separation efficiencyVSAvoidintegrated system complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The system is segmented into two independent devices: an analysis device for crossover frequency measurement and a separation device for particle separation. This segmentation allows particles to be separated after analysis, improving productivity, while avoiding the complexity of integrating both functions into a single system. The simplified electrodes in the analysis device contribute to this reduced complexity.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables straightforward analysis of crossover frequencies and effective separation of dielectric particles, reducing the complexity of positioning particles between fine microelectrodes and allowing for the use of particles post-analysis, while also simplifying conductivity adjustments and reducing analysis variations.

Implementation Method 1

analyzing a crossover frequency at which a dielectrophoretic force on dielectric particles switches from a repulsive force to an attractive force or from the attractive force to the repulsive force

Methodology Applied
Scientific EffectDielectrophoresis:

Implementation Method 2

an imaging unit for capturing an image of a movement trajectory of each of the dielectric particles flowing between the pair of electrodes

Methodology Applied
Scientific EffectOptical imaging:

Data Source

PatentEP3410107B1Analysis device and separation device
Publication Date: 2021.11.03 AFI CORP
  • EP3410107B1 patent drawingFigure 1
  • EP3410107B1 patent drawingFigure 2
  • EP3410107B1 patent drawingFigure 3

AI summary

An analysis device (200) analyzes a crossover frequency at which a dielectrophoretic force on dielectric particles switches from a repulsive force to an attractive force or from the attractive force to the repulsive force, comprising a flow channel (5), a pair of electrodes (22, 23), a power supply (24), an imaging unit (25) and an analyzer (26). Through the flow channel (5), a sample solution containing the dielectric particles in the dielectrophoretic liquid flows. The pair of electrodes (22, 23) are arranged in the first channel. The power supply (24) applies a frequency-modulated AC voltage to the first electrodes (22, 23). The imaging unit (25) captures an image of a movement trajectory of each of the dielectric particles flowing between the electrodes (22, 23) in the flow channel. The analyzer (26) obtains the crossover frequency of the dielectric particles based on the captured image of the movement trajectory.