Diene Compounds Inhibit UV-Induced DNA Damage
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Solution Overview
Problem
Current compounds and compositions do not effectively address DNA damage caused by UV radiation, which is a major factor in skin cancer development, and lack measures to prevent or treat DNA damage induced by environmental agents like UV radiation.
Innovation Solution
Compounds of the general formula CH3-(CH=CH)n-R, where n=3, 5, 7, with specific functional groups and pharmaceutically acceptable salts, are topically administered to inhibit DNA damage, preserve cell viability, and prevent apoptosis, specifically targeting UV-induced DNA damage in skin cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If conventional compounds are used for skin protection, then general skin care functions are provided, but DNA damage from UV radiation is not effectively prevented
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of retinoid compounds to create diene derivatives with specific molecular configurations (formula CH3-(CH=CH)n-R where n=2-7). These structural parameter changes enhance the compounds' ability to interact with DNA and protect against UV-induced damage, specifically preventing pyrimidine dimer formation while maintaining skin compatibility.
Solution Approach 2:
The invention employs composite materials by formulating diene compounds in combination with other active ingredients and excipients to create multifunctional cosmetic compositions. These composite formulations integrate DNA protection, antioxidant, and skin conditioning properties, providing comprehensive protection against UV damage while addressing multiple skin care needs simultaneously.
2Reliability
If DNA repair mechanisms are enhanced, then protection against mutations is improved, but the complexity of the treatment increases
Solution Approach 1:
The patent applies self-service by utilizing the body's natural DNA repair pathways (nucleotide excision repair and base excision repair) and enhancing them through topical application of diene compounds. The compounds work by preventing DNA damage in the first place and supporting the skin's endogenous repair mechanisms, rather than requiring complex external intervention systems.
Solution Approach 2:
The invention implements preliminary action by applying diene compounds before UV exposure to prevent DNA damage occurrence. The compounds pre-position protective molecular structures on DNA, creating a preventive barrier that stops pyrimidine dimer formation before it can happen, rather than attempting to repair damage after it occurs.
Data Source
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AI summary
The invention relates to compounds of general formula (I): CH3-(CH=CH)n-R (I) wherein n = 3, 5, 7; R is selected from -CO-OR', -CO-O(-), or -CH2-O-CO-R', R' being selected from H, C1-C22 alkyl or alkenyl.aryl or aralkyl, or sugars; with the proviso that when R is -CH2-O-CO-R' and R' alkyl, said alkyl being selected from C1 to C11; and pharmaceutically acceptable salts thereof, preferably such as sodium, potassium, lysine salts, each compound of general formula (I) being used as such or in admixture with one or more of the other ones, for use in the prevention or treatment of skin cancer resulting from DNA damage produced by UV radiation.