Dietary Supplement for Postprandial Glucose Control

Solution Overview

Problem

Current treatments for impaired glucose tolerance and type 2 diabetes, such as Acarbose and Metformin, are costly and have significant side effects, necessitating the development of natural, botanical strategies to control postprandial blood glucose and enhance insulin sensitivity.

Innovation Solution

A dietary supplement formulation containing standardized extracts of astragalus root, phlorizin, white mulberry root bark, olive leaf, bitter melon, 2-deoxy-D-glucose, biotin, vitamin D, and vitamin C, administered orally to inhibit glucose absorption and increase insulin sensitivity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional hypoglycemic agents (Acarbose, Metformin) are used, then glucose control efficacy is improved, but side effects and cost increase

Engineering Contradiction:

Improveglucose control efficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces expensive conventional drugs with a dietary supplement formulation using natural, plant-based ingredients that are more affordable and have fewer side effects. The formulation includes extracts from plants like bitter melon, fenugreek, and cinnamon, which are inexpensive and safe for long-term use.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent combines multiple plant extracts and natural compounds into a composite dietary supplement formulation. This includes extracts from bitter melon (Momordica charantia), fenugreek (Trigonella foenum-graecum), cinnamon (Cinnamomum verum), and other plants, creating a synergistic composite that addresses glucose control through multiple mechanisms.

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional hypoglycemic agents are used, then glucose control efficacy is improved, but cost increases

Engineering Contradiction:

Improveglucose control efficacyVSAvoidcost

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent replaces expensive conventional drugs with a dietary supplement formulation using natural, plant-based ingredients that are more affordable and have fewer side effects. The formulation includes extracts from plants like bitter melon, fenugreek, and cinnamon, which are inexpensive and safe for long-term use.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Object-affected harmful factors

If natural botanical strategies are used, then safety and cost-effectiveness are improved, but glucose control efficacy may be reduced

Engineering Contradiction:

ImprovesafetyVSAvoidglucose control efficacy

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent combines multiple plant extracts and natural compounds into a composite dietary supplement formulation. This includes extracts from bitter melon (Momordica charantia), fenugreek (Trigonella foenum-graecum), cinnamon (Cinnamomum verum), and other plants, creating a synergistic composite that addresses glucose control through multiple mechanisms.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent merges multiple plant extracts with different mechanisms of action into a single dietary supplement formulation. The combination includes compounds that inhibit carbohydrate digestion, improve insulin sensitivity, reduce glucose absorption, and provide antioxidant effects, creating a multi-faceted approach to glucose control.

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The supplement effectively reduces postprandial blood glucose levels and improves insulin sensitivity, providing a natural and safer alternative for preventing and treating type 2 diabetes and metabolic syndrome.

Implementation Method 1

2-deoxy-D-glucose has been shown to inhibit glucose absorption in the intestine

Methodology Applied

Scientific EffectCompetitive inhibition:

Implementation Method 2

Phlorizin, a compound found in apple roots, has been shown to inhibit glucose absorption

Methodology Applied

Scientific EffectTransport inhibition:

Implementation Method 3

alpha-lipoic acid, a potent antioxidant, has been shown to improve insulin sensitivity

Methodology Applied

Scientific EffectInsulin sensitization:

Implementation Method 4

Chromium, a trace element, has been shown to enhance insulin action

Methodology Applied

Scientific EffectInsulin potentiation:

Data Source

PatentUS11266668B2Dietary supplement for glycemia control and diabetes prevention

Publication Date: 2022.03.08 WORLD PHARMA TECH LLC

AI summary

A formulation for a dietary supplement includes standardized extracts of astragalus root, phlorizin, root bark of white mulberry, olive leaf, and bitter melon. The formulation may further include chromium, 2-deoxy-D-glucose, biotin, vitamin D and vitamin C. A method of controlling postprandial blood glucose includes administering the formulation for the dietary supplement to a patient.