Dietetic Composition Synergistic Antidyslipidemic Activity
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for dyslipidemia, such as statins, often cause unwanted side effects and are costly, while natural nutrient-based compositions show limited effectiveness compared to conventional drugs.
Innovation Solution
A composition combining fermented red yeast rice, polycosanols, niacin, and phytosterols/stanols in specific amounts, administered daily, demonstrating synergistic antidyslipidemic activity without side effects and reducing LDL-cholesterol levels effectively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pharmacological treatments based on statins are used to reduce cholesterol levels, then the effectiveness in treating dyslipidemia is improved, but unwanted side effects such as liver enzyme alterations and high costs occur
Solution Approach 1:
The patent replaces expensive pharmacological treatments with a dietetic composition based on natural, affordable ingredients including fermented red yeast rice, polycosanols, niacin, and phytosterols. This composition provides effective cholesterol reduction without the high costs and severe side effects of statin medications, making treatment accessible and safe for long-term use
Solution Approach 2:
The patent combines multiple natural ingredients with complementary mechanisms of action into a synergistic dietetic composition. The combination of fermented red yeast rice (inhibiting cholesterol synthesis), polycosanols (reducing LDL oxidation), niacin (lowering triglycerides and LDL), and phytosterols (blocking cholesterol absorption) creates a composite formulation that achieves superior effectiveness compared to single-ingredient approaches while avoiding pharmaceutical side effects
2Object-generated harmful factors
If natural nutrient-based compositions are used as alternative treatments, then side effects are avoided, but effectiveness is limited compared to conventional drugs
Solution Approach 1:
The patent merges multiple natural ingredients with different mechanisms of action into a unified dietetic composition. By combining fermented red yeast rice, polycosanols, niacin, and phytosterols, the formulation achieves synergistic effects that produce cholesterol reduction levels comparable to or exceeding conventional medications, while maintaining the safety profile of natural ingredients
Solution Approach 2:
The patent optimizes the dosages and ratios of each ingredient in the composition to maximize effectiveness. Specific amounts of fermented red yeast rice, polycosanols, niacin, and phytosterols are formulated to work synergistically, transforming individual moderate effects into a combined powerful antidyslipidemic action that matches or exceeds pharmaceutical efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves a significant reduction in total cholesterol levels up to 27% within two months, offering a safe and effective treatment for dyslipidemia with lower doses of active ingredients compared to conventional recommendations.
Implementation Method 1
Such active principles selectively inhibit the enzyme of hydroxymetyl-glutaryl-coenzyme A reductase (HMG-CoA- reductase), a hepatic enzyme allowing the biosynthesis of cholesterol
Implementation Method 2
niacin which inhibits the oxydation of LDL-cholesterol and reduces the lipoprotein with low density and the triglycerides
Implementation Method 3
the sterols of vegetable origin or phytosterols and the corresponding saturated derivatives, stanols, reducing the absorption of cholesterol at intestinal level
Data Source
AI summary
In a general aspect thereof, the present invention relates to a dietetic composition having an improved antidyslipidemic activity. More specifically, the present invention relates to a dietetic composition comprising a combination of a microorganism selected among the red yeasts of rice, of an aliphatic linear alcohol, of niacin or derivatives thereof and of sterols and/or stanols of vegetable origin in free or esterified form.