Differentiated MSC Biomaterial with Demineralized Bone Matrix
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Solution Overview
Problem
Current methods for producing multi-dimensional tissues for bone grafts or cartilage reconstruction face challenges in biocompatibility and mechanical properties, particularly in addressing bone or cartilage defects without causing biocompatibility issues or disease transfer.
Innovation Solution
A biomaterial composed of differentiated mesenchymal stem cells (MSCs) and demineralised bone matrix (DBM), which can be implanted in the body to provide biocompatibility and mechanical characteristics similar to natural bone or cartilage, is developed, allowing for the creation of three-dimensional structures that can be used in bone or cartilage repair.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If graft material is harvested from the individual's own bone, then biocompatibility is ensured, but additional surgery and recovery time are required
Solution Approach 1:
The invention extracts the essential function of bone grafting (biocompatible bone formation) by using demineralized bone matrix as a scaffold, while eliminating the need to harvest live bone tissue from the patient, thus removing the associated surgical trauma and recovery time
Solution Approach 2:
The patent introduces an intermediary substance (demineralized bone matrix combined with growth factors) that mediates between the patient's body and the need for bone regeneration, providing biocompatibility without requiring direct bone harvesting
2Ease of operation
If bone is taken from others or cadavers, then no additional surgery is needed for harvesting, but biocompatibility problems and disease transfer risk arise
Solution Approach 1:
The invention uses demineralized bone matrix, which removes the harmful mineral components that could cause rejection or disease transfer, while retaining the beneficial structural scaffold and growth factor reservoir properties of natural bone
Solution Approach 2:
The patent applies local quality modification by selectively removing minerals from bone matrix while preserving the organic components, creating a material with tailored properties that are both biocompatible and functionally active for bone regeneration
3Reliability
If traditional bone graft materials are used, then bone repair can be achieved, but mechanical properties and multi-dimensional tissue structure are insufficient
Solution Approach 1:
The invention creates a composite material system combining demineralized bone matrix (providing structural scaffold) with growth factors (providing biological activity), resulting in a material that simultaneously achieves mechanical support and biological bone regeneration
Data Source
AI summary
Biomaterial having a multi-dimensional structure and comprising demineralized bone matrix dispersed within differentiated mesenchymal stem cells (MSCs) tissue, wherein MSCs are adipose tissue-derived stem cells. Method for producing this biomaterial comprising incubating MSCS in osteoblastic and/or chondrongenic medium in presence of demineralized bone matrix. Use of this biomaterial for alleviating or treating a bone or cartilage defect, supporting or correcting a congenital or acquired abnormality, supporting a bon or articular bone replacement following surgery or trauma, and/or supporting a musculoskeletal implant.