Multi-Position Diffuse Spectral Data Processing for Blood Glucose Monitoring
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Solution Overview
Problem
Near-infrared spectroscopy faces challenges in accurately measuring blood glucose concentration in vivo due to interference from varying body background factors, such as metabolism, physiology, and mood fluctuations, which are difficult to account for using traditional reference-based methods.
Innovation Solution
A method involving differential processing of spectral data at arbitrary radial positions to remove common-mode interferences, eliminating the need to determine a floating reference position, and using an optical fiber probe with distinct optical fiber bundles to capture diffuse reflection light from different radial positions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If reference-based measurement is used to remove background variations, then measurement precision is improved, but device complexity increases due to the need to determine floating reference position
Solution Approach 1:
The patent segments the spectral data acquisition into multiple radial positions (first radial position and second radial position) around the light source. By dividing the measurement into spatial segments, the system can perform differential processing to eliminate common-mode interference from background variations while maintaining measurement precision without requiring complex floating reference position determination
Solution Approach 2:
The patent employs a multi-functional optical fiber probe that simultaneously performs multiple functions: illuminating the tissue, collecting diffuse reflection light at multiple radial positions, and transmitting signals. This universal probe design eliminates the need for separate reference position determination mechanisms, reducing device complexity while maintaining measurement precision
2Measurement precision
If spectral data from multiple radial positions is collected and processed, then measurement precision is improved by removing common-mode interference, but loss of time increases due to multiple measurements
Solution Approach 1:
The patent implements continuous spectral data acquisition at multiple radial positions simultaneously using an integrated optical fiber probe. By maintaining continuous measurement across all radial positions rather than sequential measurements, the system achieves common-mode interference removal without significant time loss
Solution Approach 2:
The patent merges the spectral data acquisition from multiple radial positions into a unified measurement process. By combining the collection of diffuse reflection light at different radial positions into a single integrated operation, the system achieves precise signal isolation without the time penalty of separate measurements
3Adaptability or versatility
If arbitrary radial positions are used for spectral data acquisition, then adaptability is improved, but measurement precision may worsen due to position selection variability
Solution Approach 1:
The patent creates a universal measurement approach that works across different radial positions and measurement conditions. The differential processing method is universally applicable regardless of the specific radial positions chosen, providing consistent performance across varying measurement scenarios without requiring precise position determination
Solution Approach 2:
The patent utilizes changes in the spectral parameters at different radial positions to extract glucose concentration information. By focusing on the differential changes in spectral characteristics rather than absolute values, the system maintains measurement precision while adapting to different radial position configurations
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively isolates glucose concentration signals from background variations, enhancing the accuracy and universality of blood glucose monitoring by accounting for various interference factors without requiring a specific floating reference position.
Implementation Method 1
obtaining a first spectral data for the medium at a first radial position and a second spectral data for the medium at a second radial position
Implementation Method 2
extraction of the blood glucose signal is difficult due to light scattering, in addition to light absorption, when the light passes through the body tissue
Implementation Method 3
extraction of the blood glucose signal is difficult due to light scattering, in addition to light absorption, when the light passes through the body tissue
Data Source
AI summary
A method of processing spectral data is disclosed and may include the steps of illuminating a medium to detect an inside particular component with light; obtaining a first spectral data for the medium at a first radial position and a second spectral data for the medium at a second radial position, wherein the first radial position and the second radial position are selected arbitrarily; and performing differential processing on the first spectral data and the second spectral data.