Digital Animal Recognition Test for Hepatic Encephalopathy Assessment

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Solution Overview

Problem

Existing methods for assessing hepatic encephalopathy in patients with decompensated cirrhosis are cumbersome, time-consuming, and often inaccessible to patients with color blindness or visual impairments, posing challenges in early detection and management.

Innovation Solution

A system and method utilizing a digital animal recognition test (CLART) that is color-shade parameter-free, allowing patients to complete tests on a tactile screen, and providing quick, easy-to-interpret results that can be used by both patients and practitioners for diagnosis and follow-up.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If color-based Stroop tests are used to assess hepatic encephalopathy, then the test can detect cognitive abnormalities, but the test becomes inaccessible to patients with color blindness or vision issues

Engineering Contradiction:
Improvedetection accuracy of hepatic encephalopathyVSAvoidaccessibility to color-blind and visually impaired patients
Core Design Contradiction:
Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The patent changes the test parameters from color-based recognition to shape-based recognition. Instead of requiring patients to identify colors or distinguish color shades, the CLART test uses simple geometric shapes (circle, square, triangle) that can be easily distinguished by visually impaired or color-blind patients while still effectively detecting cognitive abnormalities associated with hepatic encephalopathy.

Inventive Principle:
Principle #35Parameter changes

2Measurement precision

If complex paper-and-pencil tests are used for hepatic encephalopathy assessment, then comprehensive cognitive evaluation can be achieved, but the procedure becomes long and tedious requiring significant practitioner time

Engineering Contradiction:
Improvecomprehensive cognitive evaluation capabilityVSAvoidtest administration time and practitioner involvement
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent replaces the mechanical paper-and-pencil test system with a digital application-based system. The CLART test is delivered through a mobile application that automatically presents shape-based questions, records responses, and generates results, eliminating the need for practitioners to manually administer and score lengthy paper-based tests while maintaining comprehensive cognitive evaluation capabilities.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent segments the comprehensive cognitive evaluation into multiple simple, discrete shape-based questions rather than presenting one complex test. This allows the assessment to be completed through a series of brief, easily answerable questions that collectively provide comprehensive evaluation without requiring significant time commitment from patients or practitioners.

Inventive Principle:
Principle #1Segmentation

3Measurement precision

If detailed color-shade parameters are included in the test, then the test can differentiate subtle cognitive impairments, but the test becomes complex to explain and reproduce

Engineering Contradiction:
Improvedifferentiation of subtle cognitive impairmentsVSAvoidsimplicity of explanation and reproduction
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The patent changes the test parameters from complex color-shade differentiation to simple geometric shape recognition. This maintains the ability to detect subtle cognitive impairments through pattern recognition while dramatically simplifying the instructions and making the test easy to explain and reproduce by both practitioners and patients.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS20250040866A1System and computer method including a digital biomarker (DBM), clart, for remotely assessing hepatic encephalopathy for cirrohtic patients
Publication Date: 2025.02.06 CYBERLIVER
  • US20250040866A1 patent drawing

AI summary

The invention concerns a system for assessing hepatic encephalopathy of at least one patient P, comprising: —at least one patient application module (PM) to take at least one animal recognition test for assessing hepatic encephalopathy, and to determine test results; —at least one interpretation module (IM) receiving the test results, and configured to interpret the test results in order to determine parameters of hepatic encephalopathy such as a risk thereof, —at least one practitioner application module (DM) receiving the parameters of hepatic encephalopathy to provide a diagnosis aid to a practitioner (D). According to the invention, the animal recognition test is based on animal images (TI) and corresponding text descriptions (TT) from a junior school repertoire, for easy and rapid tests; and/or the animal recognition test is made without colour shades parameters, for colour blind patients. The invention further provides a simple interpretation of the test results.