Digital Eye Imaging for Remote Thyroid Eye Disease Scoring
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Solution Overview
Problem
Early diagnosis of thyroid eye disease is difficult due to the lack of clear prognostic symptoms, requiring in-person hospital visits for medical examinations, which hinders continuous monitoring.
Innovation Solution
A computer-implemented method using a digital camera to predict clinical activity scores for thyroid eye disease by training models to analyze conjunctival hyperemia, edema, eyelid redness, and lacrimal edema, allowing individuals to monitor their condition without professional medical devices or hospital visits.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a doctor performs a medical examination through interview and observation with the naked eye to determine a clinical activity score, then the diagnosis accuracy is improved, but the ease of operation deteriorates because it requires a hospital visit by a patient in person
Solution Approach 1:
The patent uses image data captured by a digital camera to create a visual copy of the eye condition, replacing the need for a doctor's direct observation. The system processes this image copy through machine learning models to automatically assess clinical activity score components, enabling remote monitoring without requiring the patient to visit a hospital for physical examination.
Solution Approach 2:
The patent replaces the mechanical/physical examination process (doctor's naked eye observation and interview) with an automated digital imaging and machine learning system. The machine learning model processes digital images to automatically evaluate symptoms like conjunctival hyperemia, edema, eyelid redness, and lacrimal edema, substituting the manual medical examination with an automated electronic system.
2Reliability
If early diagnosis of thyroid eye disease is attempted through clinical activity score evaluation, then the treatment effectiveness is improved, but the device complexity increases because it requires professional medical diagnostic equipment and expertise
Solution Approach 1:
The patent employs a digital camera, which is a simple and inexpensive device that ordinary people can use, to capture eye condition images. This replaces the need for complex professional medical diagnostic equipment. The camera captures images that are then processed by machine learning models, enabling early diagnosis capability using affordable, accessible technology rather than expensive specialized equipment.
Solution Approach 2:
The system enables individuals to perform self-monitoring of their thyroid eye disease condition by capturing images with a digital camera and automatically processing them through machine learning models. This self-service capability allows patients to independently track their clinical activity score components without requiring professional medical equipment or expertise, thereby reducing system complexity while maintaining early diagnosis reliability.
3Ease of operation
If continuous monitoring of thyroid eye disease is enabled without a doctor's help, then the ease of operation is improved, but the measurement precision deteriorates because it lacks professional medical examination
Solution Approach 1:
The patent implements a feedback mechanism where the machine learning model continuously processes new images captured by the patient and provides updated predictions of clinical activity score components. This feedback loop enables continuous monitoring with the ease of operation improved, while the measurement precision is maintained through repeated automated assessments that can track changes in condition over time, comparable to professional medical examination consistency.
Data Source
AI summary
According to the present application, provided is a computer-implemented method of predicting a clinical activity score for conjunctival hyperemia. The method described in the present application includes: training a conjunctival hyperemia prediction model using a training set; acquiring a first image include at least one eye of a subject and an outer region of an outline of the at least one eye; outputting, by the conjunctival hyperemia prediction model executing on a processor, a first predicted value for a conjunctival hyperemia, a first predicted value for the conjunctival edema, a first predicted value for an eyelid redness, a first predicted value for an eyelid edema, and a first predicted value for a lacrimal edema; to and generating a score for the conjunctival hyperemia based on the selected first predicted value for a conjunctival hyperemia.


