Dilution Parameter Control for Diagnostic Analyzer
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Solution Overview
Problem
Existing diagnostic systems face inefficiencies when determining the appropriate dilution ratio for specimens from new patients, as they rely on past measurement values, leading to repeated measurements and increased costs, especially in expensive hormone and tumor marker diagnostics.
Innovation Solution
An analyzing system that includes a sample processor, measurement section, and memory for storing default and user-supplied dilution parameters, allowing for retrieval and transmission of suitable dilution parameters based on measurement results to optimize specimen processing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If the dilution ratio is determined based on past measurement values, then the measurement process is automated and efficient for returning patients, but the system cannot determine an appropriate dilution ratio for new patients with no past measurement values
Solution Approach 1:
The system performs preliminary actions by pre-calculating and storing multiple candidate dilution ratios in the memory unit before actual measurement. When a new patient sample is received, the controller can immediately select from these pre-prepared dilution ratios without needing to perform iterative measurements, thus resolving the contradiction between automation and adaptability for new patients.
2Measurement precision
If the dilution ratio is gradually increased through repeated measurements to find the optimum ratio, then the system can eventually determine an appropriate dilution ratio, but the number of measurements increases and diagnostic efficiency is reduced
Solution Approach 1:
The system pre-calculates multiple candidate dilution ratios and stores them in advance, eliminating the need for iterative gradual increases in dilution ratio. The controller can directly select the most appropriate dilution ratio from the pre-stored candidates based on initial measurement results, thereby achieving accurate dilution ratio determination in a single measurement rather than through repeated testing.
Solution Approach 2:
The system uses feedback from the initial measurement result to select the appropriate dilution ratio from pre-stored candidates. The controller compares the initial measurement value with reference ranges and automatically selects the optimal dilution ratio from the pre-calculated options, avoiding the need for multiple iterative measurements while maintaining measurement precision.
3Measurement precision
If multiple measurements are performed to determine the optimum dilution ratio, then the system can find the appropriate dilution ratio, but the cost of expensive reagents increases
Solution Approach 1:
The system pre-calculates and stores multiple candidate dilution ratios before actual measurement takes place. This allows the controller to select the optimal dilution ratio in advance or after a single measurement, eliminating the need for multiple repeated measurements and thereby significantly reducing consumption of expensive reagents while maintaining measurement precision.
Data Source
AI summary
An analyzing system, comprising: a sample processor for processing a sample based on a designated dilution parameter; a measurement section for measuring the sample processed by the sample processor; a dilution parameter memory for storing a first dilution parameter and a second dilution parameter which is different from the first dilution parameter and can be supplied by a user of the analyzing system; and a measurement controller for controlling the sample processor and the measurement section so as to process the sample based on the first dilution parameter and obtain a measurement value by measuring the processed sample; wherein, when a comparison of the measurement value and a predetermined threshold indicates a retest, the second dilution parameter is used for the retest, is disclosed. A diagnostic processing device and computer program product thereof are also disclosed.