DIM-Retinoid Skin Composition for Efficacy With Fewer Side Effects

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing treatments using diindolylmethane (DIM) for skin conditions such as acne, inflammation, and aging are not as effective as desired, and often have significant side effects.

Innovation Solution

Combining DIM with a synergistic retinoid compound, such as vitamin A, to enhance treatment efficacy and reduce side effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If DIM is used alone to treat skin conditions, then the treatment has fewer side effects, but the treatment efficacy is insufficient

Engineering Contradiction:

Improvetreatment efficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent combines DIM with retinoid compounds to create a synergistic treatment approach. The composition includes both DIM and a retinoid compound working together to enhance treatment efficacy for skin conditions while managing side effects through the complementary mechanisms of the two active ingredients.

Inventive Principle:

Principle #5Merging (Combining)

2Reliability

If higher doses of DIM are used to improve treatment efficacy, then the therapeutic effect increases, but side effects increase

Engineering Contradiction:

Improvetreatment efficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

By combining DIM with retinoid compounds, the patent achieves enhanced treatment efficacy at manageable dosage levels. The synergistic interaction between the two compounds allows for effective treatment without requiring high doses of DIM alone, thereby reducing side effects.

Inventive Principle:

Principle #5Merging (Combining)

3Reliability

If existing single-component treatments are used, then the treatment is simple, but the effectiveness for acne, inflammation, and aging is insufficient

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidtreatment composition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges DIM and retinoid compounds into a single composition that addresses multiple skin concerns (acne, inflammation, aging) simultaneously. This combined approach improves effectiveness across multiple parameters while maintaining practical simplicity through a unified formulation.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The composition exhibits multi-functionality by treating multiple skin conditions (acne, inflammation, signs of aging) with a single treatment regimen. The synergistic combination of DIM and retinoid compounds provides broad-spectrum benefits for various skin concerns.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS12527765B2Composition comprising a diindolylmethane and a retinoid to treat a skin condition

Publication Date: 2026.01.20 SKINTECH LIFE SCI LTD

AI summary

Provided is a composition for use in treating a skin condition, the composition comprising:(a) a first component comprising a substituted or unsubstituted diindolylmethane compound; and(b) a second component comprising a substituted or unsubstituted retinoid compound.