Dinotefuran Pet Spray for Flea and Tick Control
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Solution Overview
Problem
Current treatments for flea and tick infestations in pets are inadequate in providing long-lasting protection and are not safe for young animals, with existing compositions often requiring frequent reapplication and potential adverse reactions.
Innovation Solution
Compositions comprising 0.1% to 1% dinotefuran, a nicotinic acetylcholine receptor inhibitor, are topically applied to pets, providing long-lasting protection against fleas and ticks, even after multiple washings, and are shown to be safe for young animals and effective for a month post-administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional flea and tick treatments are used, then initial efficacy is achieved, but protection duration is short requiring frequent reapplication
Solution Approach 1:
The patent changes the concentration parameter of dinotefuran to low doses (0.05-1.0 mg/kg body weight), which unexpectedly extends protection duration to 4 weeks or longer while maintaining efficacy, resolving the contradiction between initial efficacy and protection duration
2Reliability
If higher doses of insecticides are used, then efficacy is improved, but safety for young animals deteriorates
Solution Approach 1:
The patent inverts the expected dose-response relationship by using low doses (0.05-1.0 mg/kg) of dinotefuran, which achieves both high efficacy (100% kill rate) and improved safety for young animals, eliminating adverse reactions associated with higher doses
3Reliability
If frequent reapplication is required, then initial infestation is controlled, but productivity and convenience deteriorate
Solution Approach 1:
By changing the dose parameter to low concentrations (0.05-1.0 mg/kg) of dinotefuran, the patent extends protection to 4 weeks or longer, eliminating the need for frequent reapplication and significantly improving convenience while maintaining reliable infestation control
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dinotefuran compositions demonstrate 100% efficacy in reducing flea and tick counts within 72 hours, maintaining 99.6% effectiveness at 30 days, with no adverse reactions observed, and are safe for young animals and accidental overdose, ensuring effective and safe protection against re-infestation.
Implementation Method 1
Dinotefuran is a nicotinic acetylcholine receptor inhibitor which acts to disrupt nervous systems of insects
Data Source
AI summary
There is provided in accordance with an embodiment of the disclosure a spray-on composition for the treatment and prevention of insect or arachnid infestation on a mammal comprising between 0.1% and 1.0% by weight dinotefuran. There is also provided in accordance with an embodiment of the disclosure a method for treatment of an animal at risk of insect or arachnid infestation comprising topically administering to the coat of the animal a composition comprising between 1 and 50 mg dinotefuran per kilogram of animal weight. Optionally, topically administering includes spraying on a majority of the area of the coat of the animal.