Dinotefuran Flumethrin Topical Formulation for Parasite Control

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Solution Overview

Problem

Current topical formulations for treating flea and tick infestations in dogs and cats often fail to provide sustained protection and can cause irritation, with existing single-agent treatments being ineffective in long-term control and sometimes leading to adverse reactions.

Innovation Solution

Compositions comprising dinotefuran and flumethrin, administered topically, offer a synergistic effect in eliminating fleas and ticks with a weight ratio of 4:1 to 1:1, providing long-lasting protection even after bathing, and can be combined with antihistamines to reduce irritation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If single-agent topical formulations are used to treat flea and tick infestations, then the treatment is simple to administer, but the protection is not sustained and effectiveness is limited in long-term control

Engineering Contradiction:

Improvesimplicity of administrationVSAvoidduration of protection

Core Design Contradiction:

Ease of operationVSDuration of action of moving object

Solution Approach 1:

The patent combines two different active ingredients (dinotefuran and flumethrin) into a single topical formulation. This merging of multiple agents in one product maintains ease of administration while providing sustained protection against both fleas and ticks simultaneously, resolving the contradiction between simplicity and duration of effect.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The formulation uses a composite approach by incorporating two chemically distinct active ingredients with different modes of action and spectra of activity. This composite formulation provides long-lasting protection that neither agent could achieve alone, while remaining a simple single-application topical treatment.

Inventive Principle:

Principle #40Composite materials

2Reliability

If existing topical formulations are used to eliminate parasites, then parasite infestation is reduced, but irritation and adverse reactions occur in treated animals

Engineering Contradiction:

Improveeffectiveness in eliminating parasitesVSAvoidirritation and adverse reactions

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent optimizes the concentration parameters of the active ingredients, using dinotefuran at 5-30% and flumethrin at 0.2-5%. This parameter optimization achieves reliable parasite elimination while minimizing irritation and adverse reactions, resolving the contradiction between effectiveness and safety.

Inventive Principle:

Principle #35Parameter changes

3Duration of action of stationary object

If higher concentrations of active ingredients are used to ensure long-lasting effect, then protection duration is extended, but irritation to the treated animal increases

Engineering Contradiction:

Improvelong-lasting effectVSAvoidirritation

Core Design Contradiction:

Duration of action of stationary objectVSObject-affected harmful factors

Solution Approach 1:

The patent combines two active ingredients with different potency profiles and modes of action. This combination allows for extended protection duration through synergistic effects while using lower individual concentrations of each agent, thereby reducing irritation compared to using single high-concentration formulations.

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentUS9622478B2Topical formulations for treating parasitic infestations

Publication Date: 2017.04.18 SOLANO S P LTD

AI summary

Embodiments of the invention relate to compositions for topical administration to dogs and cats comprising the active components dinotefuran and flumethrin, and methods for the treatment and prevention of flea and tick infestation comprising topical administration of such compositions.