Dioscorea Extract Ratio for Neurotrophic Factor Stimulation
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Solution Overview
Problem
Current treatments for neurodegenerative disorders using neurotrophic factors face challenges such as side effects, limited administration amounts, and minimal regeneration of motor neurons due to the method of delivering recombinant proteins, which restricts their therapeutic efficacy.
Innovation Solution
A pharmaceutical composition and health functional food comprising a mixed extract of Dioscorea Rhizoma and Dioscorea nipponica in a weight ratio of 3.5:1, which stimulates the production and secretion of nerve growth factors, promoting neural cell proliferation and preventing apoptosis, thereby enhancing cognitive abilities and treating neurodegenerative disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If recombinant neurotrophic factors are administered to treat neurodegenerative disorders, then neural regeneration and function improvement are enhanced, but side effects and limited administration amounts occur due to injection methods
Solution Approach 1:
The patent uses Dioscorea extract as an intermediary substance that stimulates endogenous neurotrophic factor production. Instead of directly administering recombinant proteins that cause side effects, the extract acts as a mediator to trigger the body's own neurotrophic factor secretion, thereby achieving therapeutic effects with minimal harm.
Solution Approach 2:
The treatment approach enables the body to produce its own neurotrophic factors through stimulation by Dioscorea extract. This self-service mechanism eliminates the need for continuous external protein administration, reducing side effects while maintaining therapeutic efficacy through endogenous production.
2Reliability
If recombinant neurotrophic factors are administered via injection, then neural regeneration is promoted, but the administration amount is limited and toxicity occurs
Solution Approach 1:
The Dioscorea extract serves as a natural intermediary that safely stimulates endogenous neurotrophic factor production. This approach allows for higher effective amounts of neurotrophic activity without the toxicity limits imposed by direct recombinant protein administration, as the body's own production system is activated rather than overwhelmed by external proteins.
3Reliability
If multiple herbs are combined in specific ratios, then synergistic effects are enhanced for treating neurodegenerative disorders, but formulation complexity increases
Solution Approach 1:
The patent optimizes the ratio of Dioscorea Rhizoma to Dioscorea nipponica at 3.5:1, representing a parameter change that maximizes synergistic effects. This specific ratio enhances the combined therapeutic activity while maintaining manageable formulation complexity through standardized proportioning.
Data Source
AI summary
This invention relates to a pharmaceutical composition and a health functional food for preventing or improving neurodegenerative disorders comprising mixed herb extracts of Dioscorea Rhizoma and Dioscorea nipponica in a weight ratio of 3.5:1 (w/w). The herb extracts mixed Dioscorea Rhizoma and Dioscorea nipponica in a weight ratio of 3.5:1 have the synergetic effects on increasing the amount of nerve growth factor in vivo, increasing the neural cell proliferation, promoting the formation of neuritis and enhancing cognitive abilities. Thus, the herb extracts of the present invention may be used for a pharmaceutical composition and a health functional food for preventing or treating neurodegenerative disorders.