Diosmin Hydrogen Sulfate Derivative for Weight Regulation
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Solution Overview
Problem
Current anti-obesity drugs have limited efficacy and are associated with significant adverse reactions, necessitating the development of new weight imbalance regulators with improved safety and effectiveness.
Innovation Solution
The use of a diosmin hydrogen sulfate derivative, including its metal salts and metal complexes, as a weight imbalance regulator or synergist, which can be administered orally to regulate body weight imbalance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If existing anti-obesity drugs (phentermine, lorcaserin, orlistat, liraglutide) are used to reduce body weight, then weight reduction effect is achieved, but adverse reactions and safety risks increase
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of diosmin through sulfation to create diosmin hydrogen sulfate and its derivatives. This structural parameter change transforms the compound into a new substance with improved pharmacological properties, achieving weight reduction through regulation of energy metabolism and lipid metabolism while reducing adverse reactions compared to existing anti-obesity drugs
Solution Approach 2:
The patent creates composite pharmaceutical formulations by combining diosmin hydrogen sulfate derivatives with other active ingredients or excipients. This composite approach enhances the therapeutic effect for weight management while mitigating potential side effects through synergistic interactions among components
2Object-affected harmful factors
If lifestyle interventions (diet and exercise) are implemented to reduce body weight, then health improvement is achieved, but patient compliance and effectiveness decrease due to difficulty in changing lifestyle
Solution Approach 1:
The patent introduces diosmin hydrogen sulfate derivative as a pharmaceutical intermediary that mediates the weight reduction process. Instead of relying solely on difficult lifestyle changes, the drug acts as a mediator to regulate metabolism and reduce appetite, making weight management more achievable and compliant for patients while still promoting healthy lifestyle adjustments
3Productivity
If orlistat is used as a lipase inhibitor to reduce fat absorption, then weight reduction is achieved, but digestive function and nutrient absorption are damaged
Solution Approach 1:
The patent applies parameter changes by using diosmin hydrogen sulfate derivatives with different chemical structures and mechanisms of action compared to orlistat. The compound regulates energy metabolism and lipid metabolism through metabolic pathways rather than directly inhibiting lipase, achieving weight reduction while preserving digestive enzyme function and nutrient absorption capabilities
Data Source
AI summary
A compound for regulating body weight imbalance, a composition thereof and an application thereof. The inventor unexpectedly discovered that diosmin hydrogen sulfate derivatives have the effects of regulating body weight imbalance, and are expected to be developed as safe and effective weight imbalance regulators or used as synergists to improve the regulatory effects of existing weight imbalance regulators.