Dipeptide Oral Care Compositions for Selective Microbiota Control
Solution Overview
Problem
Current oral care technologies fail to effectively promote the growth and colonization of beneficial oral bacteria while inhibiting pathogenic bacteria, leading to inadequate prevention of periodontal diseases and tooth decay.
Innovation Solution
An oral care composition containing specific dipeptides, such as Ser-Leu, Ser-Val, and Phe-Glu, that selectively promote the growth and biofilm formation of beneficial bacteria like Streptococcus mitis and Streptococcus salivarius, while minimizing the growth and biofilm formation of pathogenic bacteria like Streptococcus mutans and Aggregatibacter actinomycetemcomitans.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional oral care products are used, then general oral hygiene is maintained, but beneficial oral bacteria are not selectively promoted while pathogenic bacteria persist
Solution Approach 1:
The patent changes the chemical parameter by using specific dipeptides (Ser-Leu, Ser-Val, Phe-Glu) instead of conventional broad-spectrum antibacterials. These dipeptides selectively promote beneficial bacteria growth while inhibiting pathogenic bacteria, resolving the contradiction between general hygiene maintenance and selective bacterial promotion.
Solution Approach 2:
The invention applies different functional properties to different bacterial types: beneficial bacteria receive growth promotion through specific dipeptide substrates, while pathogenic bacteria experience inhibition. This local differentiation resolves the contradiction by treating bacterial populations differently based on their health impact.
2Object-affected harmful factors
If broad-spectrum antibacterials are used to reduce pathogenic bacteria, then pathogenic bacterial load decreases, but beneficial bacteria are also inhibited
Solution Approach 1:
The patent introduces dipeptides as intermediary substances that mediate between the oral environment and bacterial populations. These dipeptides serve as selective substrates that beneficial bacteria can utilize for growth while pathogenic bacteria cannot effectively use, allowing differential control without direct antibacterial action.
Solution Approach 2:
The invention converts the concept of antibacterial action from harmful (killing all bacteria) to beneficial (selectively promoting good bacteria). By using dipeptides as prebiotic substrates, the system indirectly suppresses pathogenic bacteria through competitive exclusion while actively benefiting beneficial bacteria.
3Quantity of substance
If selective prebiotic substrates are used to promote beneficial bacteria, then beneficial bacteria colonization increases, but pathogenic bacteria may still proliferate
Solution Approach 1:
The patent applies preliminary anti-action by selecting dipeptides that have inherent selective properties: they are metabolized by beneficial bacteria to promote their growth, while pathogenic bacteria are simultaneously inhibited. This dual action prevents pathogenic proliferation before it can establish itself.
Solution Approach 2:
The invention uses composite dipeptide formulations (Ser-Leu, Ser-Val, Phe-Glu) that combine multiple amino acid sequences with different selective profiles. This composite approach ensures broad-spectrum selectivity, promoting various beneficial bacteria while inhibiting multiple types of pathogenic bacteria simultaneously.
Data Source
AI summary
The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.