N-Alkyl N,N-Dipropionic Acid Benzyl Ammonium Chloride Preservatives
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Solution Overview
Problem
Current antimicrobial preservatives used in personal and home care products are often toxic, environmentally harmful, and incompatible with anionic surfactants, posing challenges in maintaining product safety and efficacy across a broad pH range.
Innovation Solution
Development of N-Alkyl, N,N-dipropionic acid, N-benzyl ammonium chloride compounds, which are synthesized through specific chemical reactions and are compatible with anionic surfactants, offering broad-spectrum antimicrobial activity across acidic and alkaline pH ranges.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional antimicrobial preservatives (parabens, formaldehyde releasers, halogenated chemicals) are used, then antimicrobial activity is improved, but toxicity to human and environment increases
Solution Approach 1:
The patent changes the chemical structure parameters of conventional quaternary ammonium compounds by replacing methyl groups with dipropionic acid groups (N,N-dipropionic acid substitution). This structural modification reduces toxicity while maintaining antimicrobial activity, resolving the contradiction between effectiveness and safety
Solution Approach 2:
The invention creates a composite molecular structure combining the antimicrobial cationic quaternary ammonium core with biocompatible dipropionic acid side chains. This composite approach maintains the beneficial antimicrobial properties while eliminating the toxic effects of traditional preservatives
2Reliability
If cationic antimicrobials (quaternary ammonium compounds) are used, then antimicrobial activity is improved, but compatibility with anionic surfactants deteriorates due to neutralization
Solution Approach 1:
The patent applies local quality modification by introducing dipropionic acid groups at specific positions on the quaternary ammonium molecule. This localized structural change reduces the overall cationic charge density, allowing compatibility with anionic surfactants while preserving antimicrobial activity at the active site
Solution Approach 2:
The invention changes the electrostatic parameters of the antimicrobial compound by substituting highly charged methyl groups with less charged dipropionic acid groups. This parameter change reduces charge neutralization with anionic surfactants, preventing formulation instability
3Reliability
If broad spectrum antimicrobial coverage is achieved, then preservation efficacy is improved, but eco-toxicity increases
Solution Approach 1:
The patent modifies the chemical parameters of conventional broad-spectrum antimicrobials by introducing biodegradable dipropionic acid groups. This structural parameter change maintains broad-spectrum activity against bacteria, fungi, and algae while improving environmental fate and reducing eco-toxicity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compounds effectively preserve personal and home care products by maintaining antimicrobial activity in the presence of anionic surfactants and across a wide pH range, providing a non-toxic, bio-degradable alternative to traditional preservatives.
Implementation Method 1
N-Alkyl, N,N-dipropionic acid, N-benzyl ammonium chlorides... exhibit broad spectrum antimicrobial activity and are useful as preservatives in home and personal care compositions
Data Source
AI summary
Disclosed herein are antimicrobial N-Alkyl-N,N-bis(2-carboxyethyl)-N-benzyl ammonium chlorides of Formula I for preservation of home and personal care products. The invention further discloses a process for preparation of the antimicrobial compounds and home & personal care compositions comprising the N-Alkyl-N,N-bis(2-carboxyethyl)-N-benzyl ammonium chlorides of Formula IR=C8-18 saturated or unsaturated alkyl group.