Disc-Like Therapeutic Factor Concentrator for One-Step Separation

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Solution Overview

Problem

Existing methods for isolating and concentrating therapeutically active factors from mammalian body fluids are inefficient, requiring multiple steps and being time-consuming.

Innovation Solution

A disc-like apparatus with a porous filter element or membrane is used for one-step concentration and separation of therapeutic factors from mammalian body fluids, allowing for expansion or increase in the amount of therapeutic factors.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If multiple steps or devices are used to concentrate therapeutic factors, then concentration effectiveness is improved, but process complexity and time consumption increase

Engineering Contradiction:

Improveconcentration of therapeutic factorsVSAvoidnumber of steps or devices

Core Design Contradiction:

Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent combines multiple functions (filtration, concentration, and expansion of therapeutic factors) into a single apparatus. The disc-like structure integrates a porous filter element that simultaneously performs separation and concentration in one step, eliminating the need for multiple sequential devices or process steps while achieving effective therapeutic factor concentration.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The apparatus is designed to perform multiple functions simultaneously: filtering body fluid, concentrating therapeutic factors, and expanding the amount of therapeutic factors. This multi-functional design resolves the contradiction by achieving high concentration effectiveness through a single unified device rather than requiring multiple specialized devices.

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Reliability

If traditional methods are used to isolate therapeutic factors, then separation is achieved, but time consumption increases

Engineering Contradiction:

Improveseparation effectivenessVSAvoidtime consumption

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The apparatus performs preliminary concentration and separation actions within the single device before final therapeutic use. The porous filter element is pre-configured to immediately begin concentrating therapeutic factors as body fluid is introduced, eliminating the need for sequential processing steps and reducing overall time consumption while maintaining reliable separation.

Inventive Principle:

Principle #10Preliminary action

3Quantity of substance

If conventional concentration methods are used, then therapeutic factors are isolated, but process efficiency decreases

Engineering Contradiction:

Improveamount of therapeutic factorsVSAvoidprocess efficiency

Core Design Contradiction:

Quantity of substanceVSProductivity

Solution Approach 1:

The patent merges isolation, concentration, and expansion functions into one integrated process within the disc-like apparatus. This combining of functions achieves both high therapeutic factor concentration and improved process efficiency by eliminating the inefficiencies associated with multiple sequential operations, thereby resolving the contradiction between quantity achieved and process efficiency.

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The apparatus effectively concentrates therapeutic factors such as growth factors, cytokines, and proteins, achieving a significant increase in their concentration and amount in the therapeutic fluid, making it suitable for treating damaged mammalian tissue.

Implementation Method 1

at least one porous filter element or membrane located inside of the compartment

Methodology Applied

Scientific EffectFiltration: Filter (physical)

Implementation Method 2

centrifuging the body fluid in the apparatus

Methodology Applied

Scientific EffectCentrifugal separation: Centrifugal Separation

Data Source

PatentUS12330172B2Method of use of cellular component concentrator and filter apparatus

Publication Date: 2025.06.17 ARTHREX INC

AI summary

The present disclosure describes a disc-like apparatus and method of its use allowing for the one-step concentration and separation of therapeutic factors found in mammalian body fluid.