Disintegrable GI Sleeve for Metabolic Disorder Treatment
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Solution Overview
Problem
Conventional surgical procedures for treating metabolic disorders like type 2 diabetes and obesity come with high morbidity and mortality rates, and there is a need for a safer, less invasive method to modulate physiological responses to ingested food.
Innovation Solution
A gastrointestinal device with a disintegrable sleeve containing non-erodible and erodible segments is designed to fit within the gastrointestinal system, allowing for controlled erosion and separation, reducing contact between ingested material and the luminal wall, and featuring an anchoring system for secure placement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional surgical procedures (gastric remodeling, gastric bypass) are used to treat metabolic disorders, then treatment effectiveness is improved, but morbidity and mortality rates increase significantly
Solution Approach 1:
The patent introduces a disposable gastrointestinal liner as an intermediary device that can be placed within the gastrointestinal tract to achieve surgical effects without performing actual surgery. The liner acts as a mediator between the patient's anatomy and the desired therapeutic outcome, reducing direct surgical intervention and associated risks
Solution Approach 2:
The patent employs a disposable gastrointestinal liner that is intended for single-use and then discarded. This approach eliminates the need for permanent implants or complex reversible surgical procedures, reducing long-term complications and mortality risks while maintaining treatment effectiveness during the liner's functional period
2Reliability
If invasive surgical procedures are performed to modulate gastrointestinal signaling pathways, then treatment efficacy for metabolic disorders is improved, but patient safety and comfort deteriorate due to high complication rates
Solution Approach 1:
The gastrointestinal liner serves as a protective intermediary that modifies the gastrointestinal environment without requiring invasive surgical alteration of anatomy. It achieves therapeutic effects by contacting and modulating the gastrointestinal tract lining, thereby improving patient safety while maintaining treatment efficacy
Solution Approach 2:
The patent utilizes a flexible liner made of thin film material that can conform to the gastrointestinal tract's shape and movements. This flexible shell approach avoids rigid surgical modifications, reducing tissue trauma and complication rates while effectively delivering therapeutic action through the liner's surface
3Ease of operation
If laparoscopic techniques are used to reduce surgical complications, then ease of operation is improved, but operative risk remains high and surgeon skill requirements increase
Solution Approach 1:
The patent replaces complex mechanical surgical procedures with a simpler device-based approach. Instead of performing intricate laparoscopic surgeries, the treatment is achieved by placing a pre-fabricated gastrointestinal liner, substituting complex surgical mechanics with a straightforward device implantation process that reduces operative risk
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively treats metabolic disorders by reducing fat digestion and hormonal release, delaying carbohydrate absorption, and promoting the release of appetite-reducing hormones, thereby addressing the challenges of surgical invasiveness and complication rates.
Implementation Method 1
the disintegrable sleeve contains a plurality of non-erodible segments connected by erodible portions, such that, upon erosion of the erodible portions, the non-erodible segments can separate
Data Source
AI summary
The invention features a gastrointestinal device and methods of use thereof for the treatment of metabolic disorders. The gastrointestinal device features disintegrable sleeve configured to fit within a patient's duodenum and to carry fluid (e.g., liquid or semisolid material, for example, chyme and digestive secretions) from its proximal end to its distal end.