Disodium 5'-Guanylate Crystallization Without Organic Solvents
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Solution Overview
Problem
The preparation of disodium-5'-guanylate crystals using hydrophilic organic solvents is costly and deviates from environmental sustainability principles, necessitating a process improvement.
Innovation Solution
A method involving the use of an aqueous solvent system, where an aqueous sodium chloride solution is mixed with an aqueous disodium-5'-guanylate solution, followed by concentration and seed addition to transform amorphous crystals into columnar crystals, without the use of organic solvents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If hydrophilic organic solvents are used in the crystallization process, then the crystallization efficiency is improved, but the production cost increases and environmental sustainability deteriorates
Solution Approach 1:
The patent changes the fundamental parameter of the solvent system from organic to aqueous-based. By using sodium chloride solution instead of hydrophilic organic solvents, the process eliminates the need for expensive organic solvents while maintaining crystallization functionality through salting-out effects and controlled supersaturation
Solution Approach 2:
The patent replaces expensive organic solvents with inexpensive aqueous sodium chloride solution. The sodium chloride solution serves as a cheap, readily available alternative that achieves the same crystallization purpose without the high cost and environmental burden of organic solvents
2Productivity
If hydrophilic organic solvents are used in the crystallization process, then the crystallization efficiency is improved, but the environmental sustainability deteriorates
Solution Approach 1:
The patent converts the typically harmful organic solvents into a beneficial aqueous system. By using sodium chloride solution, the process transforms a potentially polluting procedure into an environmentally friendly one, leveraging the benign properties of water and salt while achieving effective crystallization
Solution Approach 2:
The patent fundamentally changes the solvent parameter from organic to aqueous, eliminating environmental harm associated with organic solvent disposal while maintaining crystallization efficiency through controlled concentration and salting-out mechanisms
3Device complexity
If amorphous crystals are formed during concentration, then the crystallization process is simplified, but the product stability and quality deteriorate
Solution Approach 1:
The patent introduces seed crystals at the appropriate stage during concentration to guide the formation of stable columnar crystals from the beginning. This preliminary action prevents the formation of unstable amorphous crystals and ensures product quality while maintaining process simplicity
Solution Approach 2:
The patent uses seed crystals as an intermediary to mediate the transformation from amorphous to stable columnar crystal form. The seeds act as templates that guide the organized growth of stable crystals, ensuring product reliability without complicating the overall process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method achieves high yield and environmental friendliness by producing disodium-5'-guanylate crystals with enhanced storage and distribution stability, containing 500 ppm to 20,000 ppm chlorine ions, while avoiding the use of organic solvents.
Implementation Method 1
adding an aqueous sodium chloride solution to an aqueous disodium-5'-guanylate solution; concentrating the mixed solution... and precipitating amorphous crystals of disodium-5'-guanylate
Implementation Method 2
adding seeds to the mixed solution... to transform the amorphous crystals of disodium-5'-guanylate into columnar crystals
Implementation Method 3
concentrating the mixed solution of the aqueous disodium-5'-guanylate solution and the aqueous sodium chloride solution
Data Source
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AI summary
The present disclosure relates to a method for preparing disodium-5'-guanylate crystals, comprising: a mixing step of adding an aqueous sodium chloride solution to an aqueous disodium-5'-guanylate solution; a concentration step of concentrating the mixed solution of the aqueous disodium-5'-guanylate solution and the aqueous sodium chloride solution and precipitating amorphous crystals of disodium-5'-guanylate; and a transition step of adding seeds to the mixed solution of the aqueous disodium-5'-guanylate solution and the aqueous sodium chloride solution to transform the amorphous crystals of disodium-5'-guanylate into columnar crystals. According to the present disclosure, the disodium-5'-guanylate crystals can be produced in high yield by an environmentally friendly method without the use of organic solvents.