Disordered Rebaudioside M–D Compositions for Water Solubility
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Solution Overview
Problem
Rebaudioside M exhibits poor aqueous solubility, limiting its effective use in beverage formulations, and there is a need for compositions with improved solubility and methods to prepare such compositions.
Innovation Solution
The development of disordered crystalline compositions comprising rebaudioside M and rebaudioside D, prepared by heating a mixture with a solvent and removing it through methods like spray-drying, resulting in improved solubility and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If crystalline rebaudioside M is used in beverage formulations, then the sweetness intensity is sufficient (0.3% concentration), but the aqueous solubility is poor and dissolution is limited
Solution Approach 1:
The patent applies parameter changes by transitioning rebaudioside M from a crystalline state to an amorphous state, fundamentally altering its physical parameters. This phase change eliminates the ordered crystal lattice structure, thereby dramatically improving aqueous solubility and dissolution characteristics while maintaining the required sweetness intensity at 0.3% concentration in beverage formulations
Solution Approach 2:
The patent employs composite materials by formulating rebaudioside M with rebaudioside D in specific ratios (75-90% rebaudioside M and 5-25% rebaudioside D). This composite approach creates a synergistic effect where the combination of different steviol glycosides in amorphous form provides both the required sweetness intensity and significantly enhanced solubility compared to pure crystalline rebaudioside M
2Ease of operation
If amorphous composition is used to improve solubility, then aqueous solubility increases, but long-term stability and solubility maintenance over extended periods remains insufficient
Solution Approach 1:
The patent resolves the stability issue by creating a composite material system combining rebaudioside M and rebaudioside D in amorphous form. The specific ratio range (75-90% rebaudioside M, 5-25% rebaudioside D) creates a stable amorphous matrix that maintains solubility over extended periods. The presence of rebaudioside D appears to stabilize the amorphous structure, preventing recrystallization and maintaining solubility for greater than 5 hours at concentrations of 0.3%-0.5%
Solution Approach 2:
The patent applies local quality by creating a specific compositional environment where rebaudioside D is distributed within the rebaudioside M matrix at controlled ratios. This local compositional arrangement provides stabilizing effects that prevent the amorphous structure from collapsing or recrystallizing over time, thereby maintaining solubility characteristics throughout the product shelf life
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions achieve solubility of 0.3% or greater in water and remain soluble for extended periods, enhancing their usability in beverages and other sweetened products.
Implementation Method 1
heating a mixture of rebaudioside M, rebaudioside D and solvent, maintaining the mixture at an elevated temperature for a period of time to provide a concentrated solution
Implementation Method 2
removing solvent from the concentrated solution... The solvent can be removed by methods including, but not limited to, spray-drying
Data Source
AI summary
Rebaudioside M compositions with improved aqueous solubility and methods for preparing the same are provided herein. The rebaudioside M compositions include (i) disordered crystalline compositions comprising rebaudioside M and rebaudioside D, (ii) spray-dried compositions comprising rebaudioside M, rebaudioside D and steviol glycoside mixtures and/or rebaudioside B and/or NSF-02, (iii) spray-dried compositions comprising rebaudioside M, rebaudioside D and at least one surfactant, polymer, saponin, carbohydrate, polyol, preservative or a combination thereof. Sweetened compositions, such a beverages, containing the rebaudioside M compositions with improved water solubility are also provided herein.