Disposable Blood Introduction System for Portable Coagulation Monitoring
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current coagulation monitoring devices face challenges in point-of-care settings due to the need for manual blood introduction and the importance of sterility, which complicates the measurement of coagulation response in trauma patients.
Innovation Solution
A portable coagulation monitoring device using glass-filled thermoplastic polymer plates with a disposable blood introduction system that allows for automatic blood dosing and optical detection of coagulation response, enabling rapid and sterile measurement of blood coagulation without the need for external reagents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual blood introduction is used in coagulation monitoring devices, then the device structure can be simpler, but sterility is compromised and operation becomes more complex
Solution Approach 1:
The patent employs a disposable blood introduction system where a sterile barrier is used only once to introduce blood into the measurement chamber. This disposable component maintains sterility without requiring complex sterilization mechanisms in the main device, as the barrier is discarded after single use.
Solution Approach 2:
The blood introduction system is segmented into separate components: a disposable sterile barrier, a blood introduction mechanism, and the main measurement device. This segmentation allows the sterile function to be isolated in a disposable component, maintaining sterility while keeping the main device structure relatively simple.
2Measurement precision
If automatic blood dosing is implemented, then measurement precision improves, but device complexity increases
Solution Approach 1:
The blood introduction system is designed to automatically dose blood based on the volume of the measurement chamber. The disposable barrier and introduction mechanism work together to self-regulate blood volume without requiring complex external dosing equipment, achieving precision through the inherent design of the chamber and barrier.
3Measurement precision
If external reagents are used in coagulation monitoring, then measurement accuracy can be improved, but the time required for measurement increases
Solution Approach 1:
The patent removes the need for external reagents by designing a system where the measurement chamber itself and the disposable barrier provide the necessary coagulation measurement environment. This extraction of reagent requirements eliminates the time needed for reagent preparation, addition, and mixing, while maintaining measurement accuracy through the specialized chamber design.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides efficient and accurate measurement of coagulation response, facilitating timely diagnosis and treatment in critical situations by automating the blood introduction process and ensuring sterility, thus improving patient outcomes.
Implementation Method 1
an optical detection sensor system for detecting interaction of light with a blood sample located between the first member and second member, as an indication of coagulation response of the blood sample
Implementation Method 2
the first and second members include a glass-filled thermoplastic polymer
Data Source
AI summary
Portable coagulation monitoring devices, systems, and methods are disclosed. Namely, a test cartridge is provided for use in a portable coagulation monitor (PCM) device. Further, the test cartridge comprises two glass-filled thermoplastic polymer plates and a disposable blood introduction device. The two glass-filled thermoplastic polymer plates are arranged substantially in parallel with a small gap therebetween for receiving a sample of blood to be tested. Using the PCM device, the two glass-filled thermoplastic polymer plates can be moved linearly relative to each other. Methods of measuring coagulation response in a blood sample using the test cartridge and the PCM device are provided. A method of introducing blood into the test cartridge using the disposable blood introduction device is provided.