Disposable Chip Cartridge for Mobile Multiparameter Analysis
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Solution Overview
Problem
Existing point-of-care diagnostic systems face limitations in reproducibility, automation, and integration of biochemical analysis processes, requiring manual steps, dry reagents, and complex logistics, with inadequate calibration and contamination issues.
Innovation Solution
A disposable measuring chip cartridge module with external reagent inlets and a modular system for fluidic processing, allowing for calibration during analysis and automated sample preparation, using liquid reagents and minimizing solid reagents within the cartridge.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If manual sample preparation and processing steps are used in existing point-of-care diagnostic systems, then ease of operation is maintained, but automation level and reproducibility are insufficient
Solution Approach 1:
The system is divided into separate functional modules: a reusable control unit and disposable measuring cartridges. The cartridge contains pre-integrated reagent reservoirs, sample processing chambers, and detection components, allowing automated processing without requiring the user to manually handle individual components or steps.
Solution Approach 2:
Reagents are pre-loaded into sealed reservoirs within the disposable cartridge during manufacturing. The cartridge is prepared in advance with all necessary components for the analysis, eliminating the need for manual sample preparation steps during operation. The user simply inserts the pre-prepared cartridge and provides the sample.
2Ease of manufacture
If dry reagents are used in existing systems, then storage and logistics are simplified, but manufacturing complexity and costs increase
Solution Approach 1:
The invention changes the physical state parameter of reagents from solid (dry) to liquid form. Liquid reagents are stored in sealed reservoirs within the disposable cartridge, eliminating the need for complex dry reagent formulations while simplifying manufacturing. The liquid form allows for more straightforward filling and sealing processes during cartridge production.
3Measurement precision
If calibration is performed before analysis in existing systems, then measurement accuracy is achieved, but analysis time is increased due to waiting periods
Solution Approach 1:
The system merges the calibration function with the sample analysis function by providing separate inlet ports that allow both calibration solutions and sample solutions to be introduced into the same measuring cartridge simultaneously or in rapid succession. The control unit manages the sequencing of calibration and measurement without requiring removal or replacement of the cartridge, eliminating waiting time.
4Reliability
If integrated disposable cartridges are used in existing systems, then contamination is reduced, but device complexity and manufacturing effort increase
Solution Approach 1:
The disposable measuring cartridge is designed as a universal platform that integrates multiple functions: reagent storage, sample introduction, mixing chambers, and detection areas. This multi-functional integration is achieved through a standardized design that can accommodate different analysis types while maintaining a consistent basic structure, reducing manufacturing complexity through standardization.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances reproducibility and automation of multi-parameter analyses with reduced costs and manufacturing effort, enabling on-site, prompt analysis of chemical and biological samples.
Implementation Method 1
Said sample passes into said channel system through a capillary effect
Data Source
AI summary
The invention relates to a measuring chip cartridge module conducting mobile multi-parameter analyzes of chemical and/or biological substances, comprisinga sample inlet for the extraneous introduction of a sample substance into said measuring chip cartridge module,at least one separate reagent inlet for the extraneous introduction of reagents into said measuring chip cartridge module,a measuring chip, the surface of which—designed for sample analysis—at least partially restricts an analysis cell with two openings, such that a liquid surrounding said sample substance can pass into the analysis cell through a first opening for the sample analysis, as well asa channel system, in which said sample substance can be conveyed from said sample inlet to said analysis cell and said reagents can be conveyed from at least the one reagent inlet to said analysis cell, whereinsaid channel system has no solid reagents, preferably no other substances apart from air and/or inert gas, prior to the introduction of said sample substance via said sample inlet and/or said reagents via at least the one reagent inlet. Furthermore, the invention relates to a system containing a replaceable cartridge module and likewise replaceable reagent storage and processing module, as well as a process for conducting sample analyzes in this system.