Disposable Electrode Substrate for Accurate Cell Resistance Measurement
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Solution Overview
Problem
Existing techniques for measuring the electrical resistance of biological cells or tissues face issues with unstable measurements due to electrode contamination and require complex cleaning processes, leading to inefficiencies and inaccuracies.
Innovation Solution
An electrode substrate with a base section, extension parts, connection terminals, and engagement surfaces, along with a removal tool, facilitates easy attachment and detachment to a relay section, allowing for efficient and accurate electrical resistance measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If electrodes are immersed in culture solution for prolonged measurement, then measurement capability is maintained, but electrode contamination occurs and measurement accuracy deteriorates
Solution Approach 1:
The patent employs disposable electrode substrates that are discarded after a single use or after the cell culture experiment is completed. This eliminates the need to clean and reuse electrodes, preventing contamination accumulation and ensuring measurement accuracy throughout the experiment duration. The substrate includes electrodes that remain clean and functional for the entire measurement period.
Solution Approach 2:
The electrode substrate is designed to be discarded after use rather than cleaned and reused. This approach prevents contamination buildup on electrodes that would occur with prolonged immersion and repeated cleaning cycles, maintaining measurement precision without the harmful effects of electrode degradation from multiple cleaning operations.
2Measurement precision
If electrodes are cleaned frequently to maintain accuracy, then measurement precision is improved, but operation complexity and time consumption increase
Solution Approach 1:
By using disposable electrode substrates, the patent eliminates the need for frequent cleaning operations. The substrate is inserted once and used throughout the entire experiment without requiring intermediate maintenance, significantly simplifying operations while maintaining measurement accuracy.
Solution Approach 2:
The electrode substrate is designed to maintain its own cleanliness throughout the measurement process by being disposable. Rather than requiring external cleaning operations, the substrate serves itself by being discarded after use, eliminating the need for complex cleaning procedures and reducing operational complexity.
3Measurement precision
If electrodes are cleaned frequently to maintain accuracy, then measurement precision is improved, but measurement time and productivity decrease
Solution Approach 1:
The disposable electrode substrate eliminates time-consuming cleaning operations between measurements. The substrate remains clean throughout the experiment duration and can be quickly replaced when needed, significantly improving measurement productivity without compromising accuracy.
Solution Approach 2:
The electrode substrate enables continuous measurement operations without interruption for cleaning. The useful action of measuring electrical resistance can proceed continuously throughout the cell culture experiment, maximizing productivity while maintaining precision through the disposable nature of the substrate.
4Object-affected harmful factors
If complex cleaning procedures are implemented, then electrode contamination is reduced, but device complexity and operational difficulty increase
Solution Approach 1:
The patent replaces complex cleaning systems with a simple disposable substrate approach. Instead of implementing sophisticated cleaning mechanisms, the solution is to use a new, clean electrode substrate for each experiment or measurement session, dramatically reducing system complexity while effectively preventing contamination.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables high-efficiency and high-accuracy electrical resistance measurements by simplifying electrode replacement and reducing contamination risks, suitable for use in robot systems.
Implementation Method 1
measuring the electrical resistance of biological cells or tissues
Data Source
AI summary
A technique for measuring the electrical resistance of biological cells or tissues with high efficiency and with high accuracy is provided. An electrode substrate includes: a substrate having a base section, a first extension part extending from the base section, and a second extension part extending from the base section; a plurality of connection terminals provided on a first main surface of the substrate; a first working electrode and a second working electrode each connected to one of said connection terminals, the first and second working electrodes being wired on the first main surface of the substrate; and an engagement surface provided on the substrate and facing toward the connection terminals in a position closer to the first extension part than the connection terminals. The first working electrode is wired from the base section to the first extension part. The second working electrode is wired from the base section to the second extension part.