Disposable Spray Drying Chamber for Aseptic Plasma Powder
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing spray drying systems are impractical for use by untrained operators and fail to provide aseptic manufacturing of dried plasma, which is crucial for widespread availability of transfusable plasma, especially in emergency settings.
Innovation Solution
A disposable spray drying device with a spray drying head and chamber that efficiently dries plasma into a dried powder, maintaining integrity and allowing aseptic manufacture, suitable for use by minimally trained personnel.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If complex spray drying systems are used, then manufacturing precision and plasma drying integrity are improved, but device complexity and ease of operation deteriorate
Solution Approach 1:
The patent employs a disposable drying chamber that is discarded after a single use, eliminating the need for complex cleaning and sterilization systems. This disposable approach reduces overall system complexity while maintaining manufacturing precision through controlled single-use conditions, directly resolving the contradiction between drying integrity and system complexity.
Solution Approach 2:
The spray drying system is divided into separate functional modules: a reusable spray drying head and a disposable drying chamber. This segmentation allows the complex precision components to be reused while the simple disposable chamber handles the critical single-use drying process, reducing overall system complexity while maintaining manufacturing precision.
2Manufacturing precision
If complex spray drying systems are used, then manufacturing precision and plasma drying integrity are improved, but ease of operation deteriorates
Solution Approach 1:
By using a disposable drying chamber, the system eliminates complex operational procedures for cleaning and sterilization. Operators simply load the disposable chamber and initiate the drying process, significantly improving ease of operation while maintaining manufacturing precision through the controlled single-use environment.
Solution Approach 2:
The disposable drying chamber is pre-sterilized and prepared for use, requiring no operational intervention for sterilization or maintenance. The system performs its own integrity requirements through the pre-prepared disposable component, freeing operators from complex procedural requirements and improving ease of operation.
3Ease of operation
If disposable spray drying devices are used, then ease of operation and ease of manufacture are improved, but reliability and manufacturing precision deteriorate
Solution Approach 1:
The disposable drying chamber is designed with inherent reliability features including pre-sterilization and controlled single-use construction. This eliminates variability in cleaning and sterilization processes, actually improving reliability while maintaining ease of operation. The disposable nature ensures consistent performance without degradation from repeated use.
4Ease of manufacture
If disposable spray drying devices are used, then ease of manufacture and device simplicity are improved, but manufacturing precision and plasma drying integrity deteriorate
Solution Approach 1:
The disposable drying chamber is manufactured with integrated precision features including controlled material composition and pre-sterilization. This approach simplifies manufacturing while ensuring manufacturing precision through the controlled single-use environment, eliminating the need for complex re sterilization processes that would compromise integrity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables rapid, aseptic production of dried plasma that can be readily stored and rehydrated for use, overcoming the limitations of existing systems by providing a compact, easy-to-use solution for plasma drying.
Implementation Method 1
the pressurized aerosol gas flows in a vortex pattern, wherein, when in use, the pressurized aerosol gas atomizes the plasma entering the drying chamber to obtain atomized plasma droplets
Implementation Method 2
atomized plasma droplets evaporate in the presence of the drying gas emitted from the one or more drying gas jet to thereby obtain dried plasma particles
Data Source
AI summary
The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.