Dissolution Chamber for Bladder Photosensitizing Agent Preparation
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Solution Overview
Problem
The preparation of aqueous solutions of photosensitizing agents for bladder cancer diagnosis and treatment is cumbersome due to limited stability, requiring on-site reconstitution, which complicates logistics and increases the risk of incorrect concentrations.
Innovation Solution
A dissolution chamber integrated with a urinary catheter system that dissolves a solid photosensitizing agent with an aqueous solvent within the chamber, ensuring a ready-to-use, sterile, and accurately concentrated solution is delivered directly to the bladder, reducing contamination and logistical complexities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If photosensitizing agents are prepared as aqueous solutions for bladder instillation, then they can be administered effectively for PDD/PDT, but their limited stability in water requires on-site reconstitution which complicates logistics and increases risk of incorrect concentrations
Solution Approach 1:
The photosensitizing agent is pre-loaded in solid form into the dissolution chamber before use. The chamber is sealed and ready for transport, eliminating the need for on-site preparation steps such as weighing, transferring, and dissolving the agent. When needed, aqueous solvent is simply injected into the pre-loaded chamber to dissolve the agent in-situ, ensuring accurate concentration without complex preparation procedures.
2Ease of operation
If manual reconstitution is performed on-site, then the photosensitizing agent can be converted to usable form, but the process is cumbersome and impacts commercial acceptance
Solution Approach 1:
The dissolution chamber integrates multiple functions into a single device: it stores the solid photosensitizing agent, contains the dissolution process, and connects directly to the catheter for bladder instillation. The chamber merges the roles of container, dissolver, and delivery system, eliminating the need for separate preparation steps and reducing overall preparation time while improving ease of operation.
3Ease of operation
If ready-to-use aqueous solutions are provided, then logistics are simplified and convenience is improved, but the limited stability of photosensitizing agents in water prevents long-term storage
Solution Approach 1:
The invention changes the physical state parameter of the photosensitizing agent from dissolved (aqueous solution) to undissolved (solid form) for storage purposes. The solid agent is stable and can be stored long-term in the sealed dissolution chamber. When administration is needed, the agent is converted to dissolved form by injecting aqueous solvent into the chamber, providing the ready-to-use solution at the point of care without compromising stability during storage and transport.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method provides a convenient, sterile, and accurately dosed aqueous solution of photosensitizing agents for bladder cancer diagnosis and treatment, enhancing safety and efficiency by eliminating the need for manual reconstitution and ensuring correct concentrations.
Implementation Method 1
the chamber is arranged to promote dissolution of the solid composition by the solvent within the chamber
Implementation Method 2
using the chamber and optionally a mixer to promote dissolution
Data Source
AI summary
The invention relates to a dissolution chamber (10) for use with a catheter for dissolving and preparing an aqueous solution of a water-soluble photosensitizing agent for installation into the bladder, e.g. for use in photodynamic diagnosis (PDD) or photodynamic therapy (PDT) of bladder cancer and to a method for preparing a liquid pharmaceutical preparation for delivery into a patient's bladder which includes the use of said dissolution chamber (10).