Dissolvable Therapeutic Agent Delivery via Conduit Wall Embedding
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Solution Overview
Problem
Current methods for treating biological conduits, such as blood vessels, face challenges in effectively delivering therapeutic agents locally due to systemic exposure and the need for high doses, which can lead to unwanted side effects and restenosis issues.
Innovation Solution
A system and method for localized application of therapeutic agents using dissolvable bags or barbs that are pressed or ejected against the conduit wall, minimizing systemic exposure and using a catheter with apertures and inflatable balloons to deliver therapeutic agents directly to the affected region.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If systemic delivery of therapeutic agents is used to treat biological conduits, then the therapeutic agents can reach the affected region, but high doses are required which lead to unwanted side effects and restenosis
Solution Approach 1:
The patent applies local quality by delivering therapeutic agents directly to the affected region of the biological conduit through localized application devices. This ensures that the therapeutic effect is concentrated where needed (at the stenotic lesion or restenotic area) rather than being distributed systemically, thereby achieving effective treatment with lower overall doses and minimizing harmful side effects.
Solution Approach 2:
The patent uses an intermediary delivery system (localized application device, catheter, or implantable device) to transport and apply therapeutic agents directly to the target site within the biological conduit. This intermediary mechanism enables precise local delivery, avoiding the need for high systemic doses and reducing exposure of healthy tissues to therapeutic agents.
2Reliability
If high doses of therapeutic agents are administered systemically, then the affected region receives sufficient treatment, but unwanted side effects occur
Solution Approach 1:
By concentrating the therapeutic agent application locally at the affected site within the biological conduit, the patent achieves reliable and effective treatment of the target region without requiring high systemic doses. This localized approach ensures that sufficient therapeutic concentration is achieved where needed while minimizing exposure and harmful effects in other parts of the body.
Solution Approach 2:
The intermediary localized delivery system ensures that therapeutic agents are reliably delivered to the affected region with controlled dosing. This intermediary mechanism provides consistent and effective treatment at the target site while preventing the systemic overexposure that causes unwanted side effects.
3Object-affected harmful factors
If localized delivery of therapeutic agents is implemented, then systemic exposure is reduced, but the complexity of the delivery system increases
Solution Approach 1:
The patent employs an intermediary localized delivery system that can be integrated with existing medical devices or procedures. This intermediary approach reduces systemic exposure by targeting therapeutic agents directly at the affected region, while the modular design of the delivery system allows for integration with conventional catheters, balloons, or stents, thereby managing complexity.
Solution Approach 2:
The localized delivery system is designed with multi-functionality, capable of delivering various therapeutic agents (drugs, genes, cells) through a single platform. This universal approach reduces the need for multiple specialized devices, thereby managing system complexity while achieving reduced systemic exposure through localized delivery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for targeted delivery of therapeutic agents directly to the conduit wall, reducing systemic exposure and the need for high doses, thereby minimizing side effects and effectively preventing restenosis.
Implementation Method 1
A dissolvable bag or bolus of at least one therapeutic agent is introduced and pressed and/or sealed against the wall of conduit
Implementation Method 2
A dissolvable bag or bolus of at least one therapeutic agent is introduced and pressed and/or sealed against the wall of conduit
Implementation Method 3
catheter with apertures and inflatable balloons to deliver therapeutic agents directly to the affected region
Implementation Method 4
dissolvable barbs formed from at least one therapeutic agent are ejected from a catheter by fluid pressure, embedding in the wall of conduit
Data Source
AI summary
The invention provides a system, device and method for localized application of therapeutic substances within a biological conduit. In various embodiments, a dissolvable bag or bolus of at least one therapeutic agent is introduced and pressed and/or sealed against the wall of conduit. In other embodiments, dissolvable barbs formed from at least one therapeutic agent are ejected from a catheter by fluid pressure, embedding in the wall of conduit.