Dissolvable solid article containing Anti-bacterial actives
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Solution Overview
Problem
Dissolvable solid articles with anti-bacterial active ingredients face challenges in maintaining effective concentration levels post-dissolution and complying with regulatory limits, leading to potential over-concentration before dissolution.
Innovation Solution
A dissolvable solid article formulation comprising specific ratios of water-soluble polymers, surfactants, diaminocarboxylic acid chelants, aromatic carboxylic acids, non-aromatic organic alpha hydroxy acids, and diols, with a pH range of 3 to 5.1, ensuring controlled anti-bacterial benefit post-dissolution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the concentration of anti-bacterial active ingredient is increased to provide anti-bacterial benefit after dissolution, then the anti-bacterial efficacy is improved, but the concentration in the solid article before dissolution becomes too high and may violate regulatory limits
Solution Approach 1:
The patent changes the chemical parameters of the anti-bacterial system by using a synergistic combination of benzoic acid (0.1-6%) and sorbic acid (0.1-3%) rather than a single high-concentration anti-bacterial agent. This parameter change allows achieving the same or better anti-bacterial efficacy with lower individual concentrations, complying with regulatory limits while maintaining reliability after dissolution
Solution Approach 2:
The patent creates a composite anti-bacterial system by combining benzoic acid and sorbic acid in specific ratios within the dissolvable solid article. This composite approach leverages the synergistic effect between the two acids, where their combined anti-bacterial activity is greater than the sum of individual activities, allowing effective post-dissolution protection without exceeding concentration limits in the solid form
2Quantity of substance
If the concentration of anti-bacterial active ingredient is decreased to comply with regulatory limits, then the regulatory compliance is improved, but the anti-bacterial benefit after dissolution is reduced
Solution Approach 1:
The patent merges the functions of multiple anti-bacterial agents (benzoic acid and sorbic acid) into a unified system within the dissolvable solid article. By combining these agents in specific ratios (0.1-6% benzoic acid with 0.1-3% sorbic acid), the system achieves enhanced synergistic anti-bacterial activity that compensates for the lower individual concentrations, ensuring regulatory compliance while maintaining or improving anti-bacterial efficacy after dissolution
3Reliability
If the solid article is formulated with high concentration of anti-bacterial active ingredient, then the anti-bacterial benefit is enhanced, but the formulation stability and safety are compromised due to potential irritation and regulatory violations
Solution Approach 1:
The patent changes the formulation parameters by selecting specific anti-bacterial agents (benzoic acid and sorbic acid) with established safety profiles and limiting their concentrations to ranges that comply with regulatory standards (0.1-6% and 0.1-3% respectively). This parameter optimization ensures the formulation provides sufficient anti-bacterial benefit while minimizing potential irritation and ensuring safety for skin and hair applications
4Reliability
If the concentration of anti-bacterial active ingredient is optimized for post-dissolution efficacy, then the anti-bacterial benefit is improved, but the concentration in the solid article may still be too high before dissolution
Solution Approach 1:
The patent applies local quality by creating a concentrated anti-bacterial reservoir in the solid article form that transforms upon dissolution. The solid article contains optimized concentrations of benzoic acid (0.1-6%) and sorbic acid (0.1-3%) that are sufficiently concentrated for stability and efficacy, but upon dissolution in water (10-50 parts water to 1 part article), these concentrations are appropriately diluted to provide effective anti-bacterial protection without exceeding safety limits in the final applied formulation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation maintains anti-bacterial efficacy after dissolution while adhering to regulatory concentration limits, providing a stable and effective anti-bacterial benefit.
Implementation Method 1
diaminocarboxylic acid chelants and salts thereof
Implementation Method 2
aromatic carboxylic acid and salts thereof having an average molecular weight in acid form of from 100 to 400 daltons and having a weighted logP value at pH 4 of from -2 to 4, wherein the aromatic carboxylic acid and salts thereof having an average molecular weight in acid form of from 100 to 400 daltons and having a weighted logP value at pH 4 of from -2 to 4 is a mixture of from 0.3% to 1.5% of salicylic acid and salts thereof, and from 0.3% to 2.5% of benzoic acid and salts thereof
Implementation Method 3
non-aromatic organic alpha hydroxy acid and salts thereof, wherein the non-aromatic organic alpha hydroxy acid and salts thereof is citric acid
Implementation Method 4
from 0.1% to 2% of a diol, wherein the diol is selected from the group consisting of 1,2-hexanediol and 1,2-octanediol
Implementation Method 5
from about 20% to about 80% of a surfactant
Data Source
AI summary
Disclosed is a dissolvable solid article, comprising by weight of the article: from about 10% to about 50% of a water soluble polymer; from about 20% to about 80% of a surfactant; from about 0.5% to about 2% of diaminocarboxylic acid chelants and salts thereof having an average molecular weight in acid form of from about 250 to about 450 daltons and having a weighted logP value at pH 4 of from about -12 to about -7; from about 0.1% to about 6% of an aromatic carboxylic acid and salts thereof having an average molecular weight in acid form of from about 100 to about 400 daltons and having a weighted logP value at pH 4 of from about -2 to about 4; from about 0.1% to about 18% of an non-aromatic organic alpha hydroxy acid and salts thereof; wherein the dissolvable solid article has a pH of from about 3 to about 5.1 when dissolved with 30parts water to 1 part of the dissolvable solid article. The present invention provides dissolvable solid articles which provide anti-bacterial benefit even after dissolution of the articles, while controlling the concentration of anti-bacterial active ingredients in the solid articles.