Dissolvable Embolic Matrices for Customized Dosage Delivery
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Solution Overview
Problem
Current embolic agents are sold in prepackaged forms, limiting healthcare professionals' ability to administer customized amounts or ratios of embolics and therapeutic agents, requiring time-consuming preparation and measurement procedures.
Innovation Solution
Development of embolic compositions packaged in dissolvable matrices, such as tablets, capsules, or sheets, that allow for precise measurement and customization of embolic and therapeutic agent delivery, enabling easy adjustment of embolic amounts and ratios according to individual patient needs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If embolics are packaged in prepackaged containers (vials or syringes), then the embolic is readily available for administration, but the healthcare professional cannot administer customized amounts or ratios of embolics and therapeutic agents
Solution Approach 1:
The embolic is segmented from the prepackaged container system and presented as a loose powder or particulate material that can be freely measured and dosed. This segmentation allows the healthcare professional to administer any customized amount of embolic without being constrained by prepackaged container limitations.
Solution Approach 2:
The embolic is transformed from a fixed-quantity packaged form to a variable-quantity loose form, enabling parameter changes in the amount and ratio of embolic to therapeutic agent. This allows flexible adjustment of dosing parameters according to individual patient needs.
2Adaptability or versatility
If the healthcare professional removes embolic from prepackaged containers, weighs and measures the desired amount, and mixes with therapeutic drug, then customized amounts can be administered, but extra time is required for these preparation procedures
Solution Approach 1:
The embolic is pre-sorted and pre-measured in a loose, ready-to-use format that eliminates the need for time-consuming weighing and measuring procedures during administration. The healthcare professional can directly administer the customized amount without preliminary preparation steps.
Solution Approach 2:
The embolic formulation is designed to be self-dosing, allowing the healthcare professional to administer the exact customized amount needed without requiring external measurement tools or complex preparation procedures. The system serves its own dosing requirements.
3Adaptability or versatility
If prepackaged embolic containers are used, then the embolic is easily stored and transported, but the ratio of embolic to therapeutic agent cannot be altered for individual patients
Solution Approach 1:
The embolic packaging system is transformed from a static prepackaged container to a dynamic, flexible formulation that can be easily adjusted. The loose powder or particulate form allows dynamic modification of the embolic to therapeutic agent ratio according to individual patient requirements.
Solution Approach 2:
The loose embolic formulation serves multiple functions: it can be used with various therapeutic agents, adjusted to different ratios, and customized for different patient needs. This universal formulation replaces multiple specialized prepackaged containers.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables quick and accurate administration of customized embolic dosages, reducing preparation time and allowing for tailored treatments, improving treatment efficacy and minimizing side effects by localizing therapeutic agents at the treatment site.
Implementation Method 1
the matrix may dissolve in water, saline, plasma and/or blood
Data Source
AI summary
Described herein are compositions comprising one or more embolics attached to an inert, dissolvable matrix as well as kits comprising these novel embolic formulations. Also described are methods of making and using these embolic formulations.