Dissolvable Solid Article Composition for Preservative Limits
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Solution Overview
Problem
Existing dissolvable solid articles face challenges in maintaining preservative efficacy after dissolution while controlling the concentration of preservative ingredients, which is regulated by country-specific guidelines and can lead to manufacturing difficulties due to high preservative levels.
Innovation Solution
A dissolvable solid article composition comprising a water-soluble polymer, a surfactant, diaminocarboxylic acid chelants, aromatic carboxylic acids, phenolic derivatives, and α, β-unsaturated Aliphatic Carboxylic Acids, carefully balanced to maintain a pH of 3 to 5.5 upon dissolution, ensuring preservative efficacy and controlled ingredient concentration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the concentration of preservative ingredient is increased to provide preservative efficacy after dissolution, then preservative benefit is improved, but the concentration becomes too high in the solid articles before dissolution, causing manufacturing difficulty and regulatory compliance issues
Solution Approach 1:
The preservative system is segmented into multiple different preservative ingredients (e.g., phenoxyethanol, ethylparaben, methylparaben, sorbic acid, benzoic acid) that work synergistically. Each ingredient contributes to the overall preservative efficacy at lower individual concentrations, avoiding the manufacturing and regulatory issues associated with high concentrations of single preservatives.
Solution Approach 2:
The patent uses a composite preservative system combining multiple preservative ingredients with specific pH control agents. This composite approach creates a synergistic effect where the combination provides enhanced preservative efficacy at lower overall concentrations compared to using single high-concentration preservatives, resolving the contradiction between efficacy and manufacturability.
2Reliability
If the concentration of preservative ingredient is increased to provide preservative efficacy after dissolution, then preservative benefit is improved, but regulatory compliance becomes difficult due to upper limitation requirements
Solution Approach 1:
The preservative burden is segmented across multiple ingredients, each present at concentrations that comply with regulatory limits. The segmentation allows the system to achieve cumulative preservative efficacy while each individual ingredient remains within regulatory thresholds, ensuring compliance across different jurisdictions.
Solution Approach 2:
The patent changes the parameters of the preservative system by using multiple ingredients at optimized concentrations combined with specific pH control (maintaining pH between 3-5.5). This parameter optimization allows the system to achieve effective preservative action while staying within regulatory concentration limits for individual ingredients.
3Reliability
If the concentration of preservative ingredient is increased to provide preservative efficacy after dissolution, then preservative benefit is improved, but manufacturing of articles with desired appearance and properties becomes difficult
Solution Approach 1:
The composite preservative system with multiple ingredients and pH control agents creates a balanced formulation that maintains desired article appearance and properties. The synergistic interaction among components allows effective preservative action without the need for high concentrations that would compromise manufacturing precision and final product quality.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides sustained preservative efficacy even after dissolution, while adhering to regulatory limits on preservative concentration, thus addressing the manufacturing and regulatory challenges faced by existing technologies.
Implementation Method 1
dissolvable solid articles comprising surfactant(s) and/or other active ingredients in a water-soluble polymeric carrier or matrix... upon dissolution in water
Implementation Method 2
provide preservative efficacy even after dissolution of the articles... at least one selected from aromatic carboxylic acids and salts thereof... a phenolic derivative
Data Source
AI summary
A dissolvable solid article, comprising: water soluble polymer; a surfactant; at least one selected from diaminocarboxylic acid chelants and salts thereof; at least one selected from aromatic carboxylic acids and salts thereof; a phenolic derivative; at least one selected from α, β-unsaturated Aliphatic Carboxylic Acids, salts, and derivatives thereof; at least one selected from non-aromatic organic alpha hydroxy acids and salts thereof; wherein the dissolvable solid article has a pH of from about 3 to about 5.5 when dissolved with 20 parts water to 1 part of the dissolvable solid article. The present invention provides dissolvable solid articles which provide preservative efficacy even after dissolution of the articles, while controlling the concentrations of preservative ingredients in the solid articles.