Dissolved C60 in Limonene for Stable Nasal Liposome Delivery
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
C60 molecules are insoluble in aqueous media and tend to agglomerate in edible oils like olive oil, leading to inefficient and unstable mixtures that hinder therapeutic, nutritional, and medicinal applications.
Innovation Solution
Dissolving C60 in limonene or d-limonene at elevated temperatures to create a homogeneous and stable mixture, which is then combined with phospholipids to form liposomes for nasal administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If C60 is mixed with olive oil to prepare for therapeutic usage, then the mixture can be administered, but the C60 dissolves only to a trivial extent and tends to agglomerate, reducing bioactivity
Solution Approach 1:
The patent changes the chemical parameters of the solvent system by replacing pure olive oil with a limonene-containing composition. This parameter change dramatically increases C60 solubility from trivial levels to approximately 16.67 mg/ml, resolving the contradiction between achieving sufficient dissolution and maintaining mixture stability.
Solution Approach 2:
The patent uses a composite solvent system comprising limonene and other components rather than a single solvent. This composite approach leverages the superior solubility properties of limonene for C60 while maintaining the stability and edibility required for therapeutic administration.
2Quantity of substance
If C60 and olive oil are sonicated and stirred for five to ten days to break up clumps, then some C60 dissolves, but only a trivial amount becomes dissolved and the mixture remains subject to settling and reagglomeration
Solution Approach 1:
By changing the solvent composition to include limonene, the patent eliminates the need for prolonged sonication and stirring. C60 dissolves rapidly and completely in the limonene-containing composition without agglomeration, reducing preparation time from days to minutes while dramatically increasing the amount of dissolved C60.
Solution Approach 2:
Limonene acts as an intermediary substance that facilitates the dissolution of C60 in an edible oil matrix. The limonene-containing composition serves as a mediating solvent system that enables rapid, complete dissolution without requiring extensive mechanical energy input or time.
3Object-affected harmful factors
If C60 is dissolved in edible oil, then the mixture is edible and safe for consumption, but the solubility is no more than approximately 0.9 mg/ml and the mixture is unstable
Solution Approach 1:
The patent creates a composite solvent system based on limonene that maintains edibility and safety while achieving dramatically higher C60 solubility. The limonene-containing composition preserves the beneficial properties of natural oils while adding the superior solubility characteristics needed for effective therapeutic dosing.
Solution Approach 2:
The patent modifies the chemical composition parameters of the edible oil by incorporating limonene, which changes the solubility parameters of the system. This parameter change enables high C60 solubility while maintaining the edible and safe characteristics required for therapeutic administration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dissolved C60 mixture is highly bioactive, stable, and edible, allowing for precise dosing and effective therapeutic and nutritional benefits, with improved solubility and stability compared to olive oil mixtures.
Implementation Method 1
heating the C60 mixture to a predetermined temperature for a predetermined time period to dissolve the C60 molecules into the limonene composition
Implementation Method 2
heating the C60 mixture to a predetermined temperature for a predetermined time period
Implementation Method 3
The applicator is operably connected to the reservoir. The nasal mixture is contained in the reservoir. The nasal mixture is configured to be sprayed by the nozzle
Data Source
AI summary
A method of administering C60 to a user includes combining C60 molecules with a limonene composition to form a C60 mixture, heating the C60 mixture to a predetermined temperature for a predetermined time period to dissolve the C60 molecules into the limonene composition to form a dissolved C60 mixture, and administering the dissolved C60 mixture to a nasal cavity of the user via nasal administration.