Dissolving Microneedle Membrane Composition for Flat Demolding
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Solution Overview
Problem
Existing microneedle patches with dissolving microneedles face issues such as membrane curling and unflatness during preparation, leading to poor demoldability and increased breakage, which affects drug delivery efficiency.
Innovation Solution
A membrane composition comprising polyvinylpyrrolidone K30, polyvinylpyrrolidone K90, and mini-hyaluronic acid in specific proportions, ensuring a flat surface and easy demolding, with microneedles ranging from 100 to 1500 microns in height, enhancing dissolution rate and drug delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If dissolving microneedles are used, then drug delivery efficiency is improved and risk of drug accumulation is reduced, but membrane surface curling and unflatness occur during preparation
Solution Approach 1:
The patent changes the material composition parameters by using polyvinylpyrrolidone K30 and K90 with specific molecular weights and ratios (9-50 wt% K30, 40-90 wt% K90), along with mini-hyaluronic acid (0.09-9 wt%), to achieve both flat membrane surface and high dissolution rate without the drawbacks of conventional dissolving microneedles
Solution Approach 2:
The patent creates a composite material system combining polyvinylpyrrolidone K30, polyvinylpyrrolidone K90, and mini-hyaluronic acid in specific proportions, where the synergistic interaction between these materials achieves both manufacturing precision (flat surface) and productivity (high dissolution rate)
2Productivity
If dissolving microneedles are used, then drug delivery function is enhanced, but demoldability deteriorates due to poor releasability
Solution Approach 1:
The patent modifies the material parameters by selecting specific ratios of polyvinylpyrrolidone K30 (9-50 wt%) and K90 (40-90 wt%), combined with mini-hyaluronic acid (0.09-9 wt%), to achieve optimal balance between drug delivery performance and ease of demolding during preparation
3Reliability
If dissolving microneedles are used, then risk of microneedle breakage in skin is reduced, but membrane breakage increases during preparation
Solution Approach 1:
The patent optimizes the material composition parameters with polyvinylpyrrolidone K30 (9-50 wt%), polyvinylpyrrolidone K90 (40-90 wt%), and mini-hyaluronic acid (0.09-9 wt%) to achieve both membrane integrity during preparation (reducing breakage) and microneedle integrity in skin (preventing skewing or breakage)
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The membrane maintains a flat and non-curling surface during preparation, facilitating easy demolding and achieving high dissolution rates, enabling accurate and painless delivery of active ingredients.
Implementation Method 1
penetrates into the stratum corneum of the skin through microneedles
Implementation Method 2
the microneedle patch with dissolving microneedles needs to undergo mold filling, drying, demolding
Data Source
AI summary
An instant membrane includes a base layer and a microneedle layer. The base layer has a surface. The microneedle layer is disposed on the surface of the base layer and has a plurality of microneedles. The materials of the base layer and the microneedle layer include: 9 wt %-50 wt % polyvinylpyrrolidone K30, 40 wt %-90 wt % polyvinylpyrrolidone K90 and 0.09 wt %-9 wt % mini-hyaluronic acid.