Distal Protector With Variable-Pore Filtration And Thrombolysis
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Solution Overview
Problem
Existing distal protectors with either small or large hole diameters fail to effectively capture thrombi, leading to potential secondary blockages in finer blood vessels, thereby increasing the risk of stroke.
Innovation Solution
A distal protector with a delivery guidewire assembly, umbrella filter assembly, and coating assembly, featuring a filter membrane with adjustable hole sizes and a thrombolytic drug delivery system to capture and dissolve thrombi, respectively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the holes of the filter membrane have relatively small diameters, then large thrombi can be intercepted, but blood cannot circulate properly
Solution Approach 1:
The filter membrane features non-uniform hole distribution with different hole diameters in different regions. Larger holes are positioned in areas requiring better blood flow, while smaller holes are placed where thrombus interception is prioritized, allowing each region to optimize its function locally rather than using a uniform hole size throughout the membrane.
2Productivity
If the holes of the filter membrane have relatively large diameters, then blood circulation is improved, but only large thrombi can be intercepted and microthrombi may pass through
Solution Approach 1:
The filter membrane incorporates regions with smaller hole diameters strategically positioned to intercept microthrombi while maintaining overall blood circulation. This localized variation in hole size allows the membrane to simultaneously address both large and small thrombus interception needs without compromising blood flow in critical areas.
3Ease of manufacture
If a uniform filter membrane with fixed hole size is used, then manufacturing is simplified, but it cannot effectively treat both large and micro thrombi
Solution Approach 1:
The filter membrane is designed with spatially varying hole diameters where different regions have optimized pore sizes for capturing thrombi of different sizes. This local differentiation enhances comprehensive thrombus treatment capability while the overall membrane structure remains manufacturable using conventional techniques.
Solution Approach 2:
The hole diameter parameter of the filter membrane is varied across different regions rather than maintaining a uniform value. This parameter change allows the membrane to adapt its filtration characteristics to handle both large and micro thrombi effectively, transforming a single-parameter design into a multi-parameter optimized structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system efficiently captures and dissolves thrombi, reducing the risk of postoperative stroke by providing targeted thrombolysis and improving thrombus treatment efficacy without requiring precise hole diameters.
Implementation Method 1
a thrombolytic drug carried in the carrier, where the thrombolytic drug is configured to dissolve a thrombus at a preset rate
Data Source
AI summary
A distal protector includes a delivery guidewire assembly, an umbrella filter assembly and a coating assembly. The delivery guidewire assembly includes a delivery guidewire. The umbrella filter assembly includes an umbrella skeleton, a filter membrane and a fixed ring. The delivery guidewire detachably passes through the umbrella filter assembly. The fixed ring is disposed at a first end of the umbrella skeleton. The filter membrane covers the umbrella skeleton. A portion of the filter membrane being away from the first end of the umbrella skeleton is provided with filter holes. The coating assembly is disposed at a second end of the umbrella filter assembly being away from the fixed ring and includes a carrier and a thrombolytic drug carried in the carrier. The thrombolytic drug is configured to be released at a preset rate.