DMSO-MSM Topical Composition for Diabetic Neuropathy Pain
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Solution Overview
Problem
Current treatments for diabetic neuropathy focus on symptom management but are inadequate, leading to progressive disease and significant side effects, with a need for improved compositions to treat and prevent diabetic neuropathies.
Innovation Solution
A topical composition comprising specific ratios of solvents (water, dimethylsulfoxide, and methylsulfonylmethane), natural polyamides, compounds related to L-carnitine and carnosine biosynthesis, vitamin D3 metabolites, coenzyme Q10, purine compounds, and B vitamins, applied transdermally to alleviate diabetic neuropathic pain.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for diabetic neuropathy are used, then symptom management is provided, but the disease progresses and significant side effects occur
Solution Approach 1:
The patent applies parameter changes by modifying the chemical composition parameters of topical treatments. Specifically, it uses a combination of DMSO (dimethyl sulfoxide) at 10-50%, MSM (methylsulfonylmethane) at 5-30%, and various amino acids and vitamins in specific concentrations to achieve effective pain relief without the harmful side effects of conventional systemic medications.
Solution Approach 2:
The patent employs composite materials by creating a multi-component topical formulation that combines DMSO, MSM, amino acids (glycine, alanine, serine, valine, leucine), and vitamins (B1, B6, B12, D3). This composite composition works synergistically to treat diabetic neuropathy while avoiding the side effects associated with single-ingredient or systemic treatments.
2Object-affected harmful factors
If conventional systemic treatments are administered, then pain relief is achieved, but disease progression continues and morbidity increases
Solution Approach 1:
The patent applies segmentation by dividing the treatment approach into localized topical application rather than systemic administration. The formulation is applied directly to affected areas (feet, hands, legs), allowing concentrated treatment at the site of neuropathy while avoiding widespread systemic effects that do not prevent disease progression.
Solution Approach 2:
The patent uses DMSO and MSM as intermediary substances that facilitate the delivery of amino acids and vitamins through the skin barrier. These intermediaries enhance transdermal penetration, allowing active ingredients to reach nerve tissues effectively while maintaining localized action that addresses both pain relief and disease prevention.
3Adaptability or versatility
If topical compositions with multiple ingredients are used, then comprehensive treatment is provided, but composition complexity increases
Solution Approach 1:
The patent applies universality by designing a multi-functional topical formulation where each ingredient serves multiple purposes. DMSO acts as both a solvent and a penetration enhancer; MSM provides anti-inflammatory effects and enhances amino acid absorption; amino acids provide both structural support and metabolic functions; vitamins provide neural protection and pain relief. This multi-functionality reduces the need for multiple separate treatments.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition reduces diabetic neuropathic pain by at least 50% within 7 days and virtually eliminates pain with daily use over a month, offering superior pain relief compared to existing treatments.
Implementation Method 1
A topical composition comprising specific ratios of solvents (water, dimethylsulfoxide, and methylsulfonylmethane), natural polyamides, compounds related to L-carnitine and carnosine biosynthesis, vitamin D3 metabolites, coenzyme Q10, purine compounds, and B vitamins, applied transdermally to alleviate diabetic neuropathic pain.
Implementation Method 2
a plurality of solvents comprising at least water, dimethylsulfoxide (DMSO) and methylsulfonylmethane (MSM) present in ratios relative to each other
Data Source
AI summary
The invention provides topical compositions and methods to treat diabetic neuropathies. Compositions of the invention comprise: aqueous solvent mixtures; natural polyamides comprising large amounts of small amino acid residues; compounds characteristic of biosynthesis and metabolism of L-carnitine, carnosine, vitamin D3, vitamin B5 and vitamin B6; purines and their decomposition compounds; and coenzyme Q10.