DNA Microarray Sequencing for Integrated Data Storage and Computing
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Solution Overview
Problem
Current DNA data storage technologies focus on either writing or reading information in nucleic acid molecules, lacking an integrated platform for writing, reading, storing, and performing computations, and are inefficient in encoding and retrieving large data sets.
Innovation Solution
A fully integrated nucleic acid molecule writer/reader/storage/computation device utilizing nano-channels and sensor devices with electrically gated nano-pores for sequencing and computation, enabling high-throughput writing and reading of digital information in nucleic acid molecules.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If current DNA data storage technologies are used, then data can be stored in nucleic acid molecules, but the system lacks integration for writing, reading, storing, and computation operations
Solution Approach 1:
The patent combines writing, reading, storing, and computation operations into a single integrated nucleic acid device platform. The device integrates nucleic acid synthesis capabilities, sequencing capabilities, and computational processing in one system, eliminating the need for separate systems for each operation.
Solution Approach 2:
The nucleic acid device is designed to perform multiple functions: writing digital information into nucleic acid molecules, reading information from them, storing the molecules, and performing compute operations directly on them. This multi-functional design allows a single device to handle the entire data storage and processing workflow.
2Manufacturing precision
If base-by-base synthesis is used for writing information, then precise data encoding is achieved, but the process is time-consuming and inefficient for large data sets
Solution Approach 1:
The patent segments the nucleic acid synthesis process into modular operations that can be performed in parallel. Instead of synthesizing entire sequences base-by-base in serial, the system divides the work into smaller units that can be processed simultaneously, significantly improving throughput while maintaining accuracy.
Solution Approach 2:
The device performs preliminary actions by pre-synthesizing and storing nucleic acid components and sequences before they are needed for data writing. This allows the system to have ready-to-use building blocks available, eliminating the time-consuming base-by-base synthesis step during actual data encoding operations.
3Reliability
If separate systems are used for writing and reading information, then each system can be optimized independently, but the overall process lacks efficiency and integration
Solution Approach 1:
The patent merges the writing and reading systems into a single integrated device. The nucleic acid writer and reader share common components, control systems, and processing pathways, enabling seamless transition between writing and reading operations without requiring separate optimized systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient writing, reading, and computation of digital information in nucleic acid molecules, reducing the reliance on base-by-base synthesis and enhancing the speed and efficiency of data storage and retrieval.
Implementation Method 1
the gate voltage can be modulated with an electric charge of a translocating read component of the input nucleic acid molecule to effect a change in source-to-drain current in the gate
Data Source
AI summary
Technologies include systems, devices, and methods to write, store, read, and perform computation of digital information using nucleic acid molecules (e.g., DNA). The technologies include, for example, a device including one or more individually or block-addressable electrode micro-arrays or nano-arrays to write, store, retrieve, read, and compute/manipulate digital information.