Low Molecular DNA and Soybean Extract for Dermal Fibroblast Activation

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Solution Overview

Problem

Current cosmetic products fail to effectively activate dermal fibroblasts to increase production of extracellular matrix components like collagen and hyaluronan, leading to inadequate prevention or improvement of skin aging, particularly wrinkles and reduced skin elasticity.

Innovation Solution

A skin anti-aging agent comprising a special low molecular DNA and a soybean extract, where the DNA is a hydrolysate from fish milt with molecular weights of 12,000 or less and the soybean extract is from seeds, germs, or sprouts, synergistically promotes collagen and hyaluronan production, and regulates gene expression to enhance dermal fibroblast function.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional cosmetic products are used to prevent or improve skin aging, then some basic skin care functions are maintained, but they fail to effectively activate dermal fibroblasts to increase production of extracellular matrix components like collagen and hyaluronan

Engineering Contradiction:
Improveeffectiveness in activating dermal fibroblasts and increasing extracellular matrix productionVSAvoidproduction of collagen and hyaluronan by dermal fibroblasts
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent combines two previously separate active ingredients (DNA and soybean extract) into a single cosmetic composition. The synergistic effect of this combination effectively activates dermal fibroblasts and increases production of extracellular matrix components, resolving the contradiction between maintaining basic skin care functions and achieving effective fibroblast activation.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention uses a composite formulation containing both DNA and soybean extract as active ingredients. This composite material approach creates a synergistic effect that enhances the production of collagen and hyaluronan beyond what either ingredient could achieve alone, thereby improving the reliability and productivity of anti-aging cosmetic action.

Inventive Principle:
Principle #40Composite materials

2Reliability

If the function of dermal fibroblast is activated to increase production of extracellular matrix components, then skin aging can be prevented or improved, but existing cosmetic products do not achieve sufficient activation effect

Engineering Contradiction:
Improveskin aging prevention and improvement effectVSAvoidease of achieving sufficient fibroblast activation
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

By merging DNA and soybean extract into a single cosmetic composition, the patent achieves sufficient dermal fibroblast activation without requiring complex application procedures. The synergistic combination naturally enhances the activation effect, making it easier to achieve reliable skin aging prevention and improvement.

Inventive Principle:
Principle #5Merging (Combining)

3Quantity of substance

If DNA and soybean extract are used separately in cosmetic products, then each provides some individual benefits, but their synergistic interaction to promote collagen and hyaluronan production is not achieved

Engineering Contradiction:
Improvecollagen and hyaluronan productionVSAvoidformulation complexity
Core Design Contradiction:
Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent merges DNA and soybean extract into a single integrated formulation, achieving high levels of collagen and hyaluronan production through their synergistic interaction. This unified approach increases the quantity of extracellular matrix components without requiring complex multi-component formulations or multiple application steps.

Inventive Principle:
Principle #5Merging (Combining)

Data Source

PatentEP3677248B1Anti-aging agent for skin and Anti-aging-related gene expression regulator
Publication Date: 2024.11.20 GENETIC BIO LAB CO LTD
  • EP3677248B1 patent drawingFigure 1
  • EP3677248B1 patent drawing

AI summary

The present invention has an object to provide a skin anti-aging agent, an agent for regulating expression of anti-aging related gene, and a cosmetic product comprising the anti-aging agent or the agent for regulating expression of anti-aging related gene which are very safe and can be used reliably for a long term. The skin anti-aging agent, the agent for regulating expression of anti-aging related gene, and the cosmetic product comprising the anti-aging agent or the agent for regulating expression of anti-aging related gene of the present invention comprise a special low molecular DNA and a soybean extract, preferably a soybean sprout extract, as active ingredients. These active ingredients have activating actions on the function of the dermal fibroblast and are hence expected to prevent or improve the skin aging such as the reduction of skin firmness and elasticity, wrinkles and sagging.