DNAse Enzyme Treatment for Post-Surgical Tissue Adhesions

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current methods for treating tissue adhesions, which often occur after surgical interventions, are limited to surgical removal, which can lead to additional adhesions and complications, and there is a need for alternative non-surgical solutions to prevent or treat these adhesions effectively.

Innovation Solution

The use of an enzyme with deoxyribonuclease (DNAse) activity to degrade DNA, thereby preventing or treating tissue adhesions by disrupting the fibrin bond formation between tissue surfaces, using a pharmaceutical composition that includes a DNAse enzyme such as human DNAse1, DNAse-1-like 3, or DNAse-1-like 2, which can be administered locally or systemically.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If surgical removal is used to treat adhesions, then adhesions can be removed, but additional adhesions and complications may occur

Engineering Contradiction:

Improveadhesion removal effectivenessVSAvoidadditional adhesion formation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the mechanical surgical removal method with a biochemical approach using DNAse enzyme to degrade DNA in fibrin bonds, thereby dissolving adhesions without mechanical intervention that could cause additional tissue damage and adhesion formation

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The DNAse enzyme acts as an intermediary substance that mediates the breakdown of fibrin bonds in adhesions by degrading DNA, providing a non-invasive mechanism to dissolve adhesions without direct surgical contact that could trigger further adhesion formation

Inventive Principle:

Principle #24Intermediary (Mediator)

2Adaptability or versatility

If DNAse enzyme is used to treat adhesions, then adhesion formation is inhibited, but this is a new approach requiring validation

Engineering Contradiction:

Improvenon-surgical treatment optionVSAvoidtreatment effectiveness

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The DNAse enzyme utilizes the body's own biochemical pathways and natural healing processes, working through existing enzymatic mechanisms to degrade fibrin bonds without requiring external surgical intervention, thereby providing a treatment that integrates with the body's natural functions

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The DNAse enzyme effectively inhibits the formation and dissolution of tissue adhesions, reducing their severity and occurrence, as demonstrated by significant reduction in adhesion scores and fibrosis in experimental models, providing a non-surgical alternative to surgical intervention.

Implementation Method 1

an enzyme with deoxyribonuclease (DNAse) activity to degrade DNA

Methodology Applied

Scientific EffectEnzyme catalysis: Enzyme

Implementation Method 2

degrade DNA, thereby preventing or treating tissue adhesions

Methodology Applied

Scientific EffectHydrolysis: Hydrolysis

Data Source

PatentUS11464833B2Methods for treating or preventing tissue adhesions

Publication Date: 2022.10.11 UNIVERSITAETSKLINIKUM HAMBURG EPPENDORF

AI summary

The present invention relates to the treatment of tissue adhesions, e.g. tissue adhesions that occur after surgical interventions. More specifically, the invention refers to an enzyme having DNAse activity for use in a method of treating or preventing tissue adhesions. The invention also relates to a pharmaceutical composition that comprises an enzyme having DNAse activity for use in a method of treating or preventing tissue adhesions.