Dolichos lablab Extract for Hangover Relief and GI Protection
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Solution Overview
Problem
Current solutions fail to effectively address the alleviation of hangovers and treatment of alcoholic gastrointestinal diseases, particularly in reducing alcohol and acetaldehyde content in the blood and protecting the gastrointestinal wall from alcohol damage.
Innovation Solution
A composition containing Dolichos lablab Linn. extract as an active ingredient, which promotes the degradation of alcohol and acetaldehyde, increasing aldehyde dehydrogenase activity and protecting the gastrointestinal wall, is used in both healthy functional foods and pharmaceutical compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If alcohol is consumed to socialize or relieve stress, then social interaction and stress relief are improved, but gastrointestinal damage and hangover symptoms occur
Solution Approach 1:
The patent introduces Dolichos lablab Linn. extract as an intermediary substance that mediates between alcohol consumption and gastrointestinal damage. The extract contains active ingredients that protect the gastrointestinal mucosa from alcohol-induced injury, thereby allowing social interaction and stress relief while preventing harmful effects.
Solution Approach 2:
The patent converts the harmful effects of alcohol into beneficial outcomes by using Dolichos lablab Linn. extract to accelerate alcohol metabolism and protect the gastrointestinal system. The extract increases aldehyde dehydrogenase activity, which converts acetaldehyde (a harmful intermediate) into acetic acid more rapidly, turning the harmful alcohol metabolism process into a beneficial rapid clearance mechanism.
2Productivity
If medicines are used to activate ADH and ALDH for lowering blood alcohol concentration, then alcohol degradation is improved, but gastrointestinal protection is insufficient
Solution Approach 1:
The patent merges two functions into a single composition: alcohol degradation (via ADH and ALDH activation) and gastrointestinal protection. The Dolichos lablab Linn. extract simultaneously enhances alcohol metabolism and provides mucosal protection, combining what were previously separate functions into one integrated solution.
Solution Approach 2:
The patent uses a composite approach by formulating a composition containing Dolichos lablab Linn. extract with multiple active components. This composite natural extract provides both enzymatic activation for alcohol degradation and protective substances for gastrointestinal mucosa, achieving dual functionality through a single composite material.
3Quantity of substance
If conventional alcohol metabolism enzymes are activated, then blood alcohol concentration is reduced, but acetaldehyde toxicity and hangover symptoms persist
Solution Approach 1:
The patent applies preliminary action by pre-activating aldehyde dehydrogenase enzymes before alcohol consumption or at the moment of consumption. The Dolichos lablab Linn. extract contains substances that boost ALDH activity in advance, ensuring that when acetaldehyde is produced during alcohol metabolism, it is rapidly converted to acetic acid before it can cause toxicity or hangover symptoms.
Solution Approach 2:
The patent implements feedback mechanisms where the composition continuously monitors and responds to alcohol metabolism dynamics. The active ingredients in Dolichos lablab Linn. extract provide feedback by dynamically adjusting enzyme activation levels to match alcohol consumption rates, ensuring optimal clearance of both alcohol and acetaldehyde throughout the metabolism process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly reduces blood ethanol and acetaldehyde levels, alleviates gastrointestinal damage caused by alcohol consumption, and treats conditions like gastritis and gastric ulcers, as demonstrated by experimental data showing rapid ethanol degradation and maintained aldehyde dehydrogenase activity.
Implementation Method 1
acetaldehyde is degraded into acetic acid by aldehyde dehydrogenase (ALDH) and NAD+
Implementation Method 2
Alcohol is oxidized to acetaldehyde in the liver by alcohol dehydrogenase (ADH) and the coenzyme NAD+
Implementation Method 3
acetaldehyde and acetic acid cause lipid peroxidation, etc., which lead to cytotoxicity, headache or abdominal pain
Data Source
AI summary
The present invention relates to a composition containing Dolichos lablab Linn. extract as an active ingredient for easing hangovers, and preventing, alleviating or treating alcoholic gastrointestinal diseases, the composition having an effect in restoring gastrointestinal wall damaged by alcohol consumption, and being capable of reducing alcohol and acetaldehyde content in the blood as well as increasing aldehyde dehydrogenase activity therein. Therefore, the Dolichos lablab Linn. extract according to the present invention can be used for easing hangovers, and as healthy functional food or medicine that can prevent, alleviate or treat alcoholic gastrointestinal diseases.