Percutaneous Dome Structure for Left Ventricle Volume Reduction
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Solution Overview
Problem
Current medical therapies for chronic left ventricular dysfunction, such as ACE inhibitors and beta blockers, are ineffective in reducing mitral regurgitation and restoring cardiac function in post-myocardial infarction patients, and existing surgical methods like ventricular restoration techniques have limited clinical evidence and are invasive.
Innovation Solution
A percutaneous medical device featuring a dome structure made of shape memory material with anchor members that can transition from a compressed configuration for delivery to an expanded configuration for deployment in the heart, allowing anchor members to engage the heart wall and pull tissue into a cavity, thereby reducing mitral regurgitation and improving cardiac function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If surgical ventricular restoration techniques are used to resect aneurysm and join healthy edges of myocardium, then cardiac function can be restored, but the procedure becomes invasive with limited clinical evidence
Solution Approach 1:
The patent replaces traditional surgical mechanical intervention (sternotomy, cardiopulmonary bypass, direct suture) with a percutaneous delivery system that uses catheter-based mechanics to deploy the dome structure through vascular access, eliminating the need for open chest surgery
Solution Approach 2:
The dome structure serves as an intermediary device that can be delivered percutaneously and deployed within the ventricle to achieve ventricular restoration without requiring direct surgical manipulation of the heart muscle, bridging the gap between minimally invasive access and effective tissue repair
2Reliability
If the dome structure is made of shape memory material and biased in expanded configuration, then it can effectively reduce mitral regurgitation, but the device complexity increases
Solution Approach 1:
The dome structure utilizes shape memory material that changes its physical state (shape, rigidity) in response to temperature or other environmental parameters, allowing it to transition from a compressed delivery configuration to an expanded functional configuration once deployed in the body
Solution Approach 2:
The dome structure is self-expanding due to its biased configuration in shape memory material, eliminating the need for external expansion mechanisms or complex actuation systems during deployment - the device automatically assumes its functional shape once released from the delivery catheter
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively reduces left ventricle volume and heart wall stress, displaces the papillary muscles, and connects healthy myocardium to improve contractility, providing a minimally invasive solution for treating mitral regurgitation and restoring cardiac function.
Implementation Method 1
the dome structure is made of a shape memory material and is moveable from a first inside out and compressed configuration to a second expanded deployed configuration
Data Source
Figure 1A
Figure 1B
Figure 2A
AI summary
Device sand methods for improving cardiac function are provided. The device includes a dome structure having a top end with an engagement element disposed thereon. The dome structure is moveable from a first inside out configuration to a second deployed configuration, and the dome structure is biased in the second deployed configuration. The dome structure includes a plurality of anchor members disposed around a bottom open end of the dome structure.