Donkey Milk Infant Formula with Beta-Palmitate Lipid Mixture
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Solution Overview
Problem
Current infant formulas fail to adequately address cow's milk protein allergy and intolerance due to side effects, nutritional inadequacies, and safety concerns, particularly in preterm infants, where they do not meet the high energy and lipid requirements, and existing processing methods do not ensure health and hygiene safety.
Innovation Solution
A donkey milk-based formula fortified with a lipid mixture where 35-55% of palmitic acid is esterified in the beta position of triglycerides, combined with essential fatty acids and long-chain polyunsaturated fatty acids, is developed to mimic breast milk composition, ensuring nutritional adequacy and hypoallergenicity, and subjected to heat treatment to ensure safety and shelf life.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current infant formulas based on cow's milk protein are used, then infants receive standard nutrition, but infants with cow's milk protein allergy or intolerance experience severe allergic reactions and gastrointestinal symptoms
Solution Approach 1:
The patent extracts and eliminates cow's milk protein from the infant formula composition entirely, replacing it with donkey milk protein which has different amino acid sequence and three-dimensional structure, thereby removing the allergen while maintaining nutritional function
Solution Approach 2:
The patent changes the protein source parameter from cow's milk to donkey milk, which fundamentally alters the protein composition and allergenic properties while maintaining milk-based nutrition suitable for infants
2Object-affected harmful factors
If cow's milk is eliminated from the diet of infants with allergy or intolerance, then allergic reactions are reduced, but nutritional adequacy and energy needs are not met
Solution Approach 1:
The donkey milk-based formula serves multiple functions simultaneously: it provides complete nutrition for infant growth, supplies adequate energy and calcium, and maintains hypoallergenic properties, replacing the need for multiple separate interventions
Solution Approach 2:
The patent creates a composite nutritional formulation combining donkey milk with specific lipid mixtures (including beta-palmitate and long-chain polyunsaturated fatty acids) to achieve complete nutritional adequacy while maintaining hypoallergenic properties
3Ease of manufacture
If standard infant formulas are used for preterm infants, then basic nutrition is provided, but high energy and lipid requirements are not met
Solution Approach 1:
The patent incorporates long-chain polyunsaturated fatty acids (DHA and ARA) and beta-palmitate into the formula in advance, preparing the nutrition to meet the specific high-energy requirements of preterm infants before they begin feeding
Solution Approach 2:
The patent adjusts the lipid composition parameters of the formula, specifically increasing long-chain polyunsaturated fatty acid content and incorporating beta-palmitate, to match the elevated energy and lipid requirements of preterm infants
4Reliability
If donkey milk is used as a substitute for cow's milk, then hypoallergenicity is improved, but lipid and caloric content are insufficient
Solution Approach 1:
The patent merges donkey milk with a specially formulated lipid mixture containing beta-palmitate, long-chain polyunsaturated fatty acids, and other essential lipids, combining the hypoallergenic protein source with adequate caloric and lipid content
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The fortified donkey milk formula provides improved calcium absorption, bone mineralization, reduced constipation, and enhanced fat absorption, while being hypoallergenic and safe for infants with cow's milk protein allergy, meeting the nutritional needs of preterm and full-term infants.
Implementation Method 1
a mixture of triglycerides derived from vegetable oils wherein from 35 to 55% of the total content of palmitic acid (C16:0) is esterified in position beta (sn-2) in the molecule of glycerol
Implementation Method 2
subjected to heat treatment to ensure safety and shelf life
Data Source
AI summary
Food for subjects with allergy or intolerance to vaccine milk protein, particularly for preterm infants and/or in term infant, characterized by being based on donkey milk, raw or freeze-dried, supplemented with a lipid mixture and subsequently subjected to treatment of inactivation of pathogenic microorganisms and production method thereof.