Doped Calcium Phosphate Ceramics for Controlled Bone Graft Strength Loss

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Solution Overview

Problem

Current bone grafting materials lack the ability to provide controlled strength loss rates and biocompatibility, leading to incomplete biodegradation and residual particles, which hinders effective bone restoration and remodeling in various applications.

Innovation Solution

Development of calcium phosphate-based ceramics with specific dopants such as NaF, CaO, Ag2O, and TiO2, which alter the mechanical and degradation properties to achieve controlled strength loss and biocompatibility, allowing for tailored biodegradation rates matching tissue growth rates.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If calcium phosphate ceramics are used for bone grafting, then biodegradation occurs, but strength loss is uncontrolled and residual particles remain

Engineering Contradiction:

Improvebiodegradation timeVSAvoidstrength control

Core Design Contradiction:

Duration of action of stationary objectVSReliability

Solution Approach 1:

The patent applies parameter changes by systematically varying dopant composition (NaF, CaO, Ag2O, TiO2), dopant concentration (0-10 wt%), and sintering temperature (1000-1300°C) to precisely control the biodegradation rate and strength loss characteristics of calcium phosphate ceramics, transforming an uncontrolled process into a tunable parameter system

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs composite materials by combining calcium phosphate base material with multiple dopants (NaF, CaO, Ag2O, TiO2) in specific ratios to create a composite ceramic system that achieves synergistic effects, where the dopants collectively control degradation kinetics, mechanical strength, and biocompatibility in a coordinated manner

Inventive Principle:

Principle #40Composite materials

2Duration of action of stationary object

If calcium phosphate ceramics are used for bone grafting, then biodegradation occurs, but residual particles are generated

Engineering Contradiction:

Improvebiodegradation timeVSAvoidresidual particles

Core Design Contradiction:

Duration of action of stationary objectVSObject-generated harmful factors

Solution Approach 1:

The patent uses parameter changes by optimizing sintering temperature (1000-1300°C) and dopant composition to control particle morphology, size distribution, and crystallinity of the calcium phosphate ceramic, ensuring complete biodegradation into soluble ions without generating harmful residual particles

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the potential harm of residual particles into a benefit by carefully selecting dopants and sintering parameters that ensure complete decomposition of the ceramic material into biocompatible ions (Ca2+, PO43-, F-, etc.) that are readily absorbed and utilized by bone tissue, transforming incomplete degradation into complete beneficial assimilation

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Reliability

If calcium phosphate ceramics are doped to control strength loss, then biocompatibility improves, but manufacturing complexity increases

Engineering Contradiction:

ImprovebiocompatibilityVSAvoiddoping process

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges multiple dopant functions into a single comprehensive doping process, where NaF, CaO, Ag2O, and TiO2 are combined in predetermined ratios and applied simultaneously through conventional ceramic processing techniques, integrating multiple biocompatibility enhancements into one unified manufacturing step rather than sequential treatments

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The use of doped calcium phosphate ceramics enables controlled strength loss and biocompatibility, facilitating complete biodegradation and promoting bone remodeling with reduced residual particles, enhancing the effectiveness of bone grafting materials in various applications.

Implementation Method 1

calcium phosphate-based ceramics with specific dopants such as NaF, CaO, Ag2O, and TiO2, which alter the mechanical and degradation properties

Methodology Applied

Scientific EffectSolid solution strengthening: Solid Solution Strengthening

Implementation Method 2

physiologic dissolution, which depends on pII and composition of calcium phosphate

Methodology Applied

Scientific EffectDissolution:

Data Source

PatentUS9795716B2Resorbable ceramics with controlled strength loss rates

Publication Date: 2017.10.24 WASHINGTON STATE UNIVERSITY

AI summary

Particular aspects of the present disclosure provide bio-resorbable and biocompatible compositions for bioengineering, restoring, or regenerating tissue or bone. In one embodiment, a biocompatible composition includes a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion dopants or metal oxide dopants. The composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled strength loss under body, body fluid or simulated body fluid conditions.