DPP4 Inhibitor Treatment for Stroke Cognitive Impairment

Solution Overview

Problem

Current methods lack effective tools for predicting and treating stroke-induced cognitive impairment in patients undergoing mechanical thrombectomy, leading to significant cognitive disabilities and a poorer prognosis.

Innovation Solution

A method involving the detection of specific target proteins in blood samples, such as ANG, ARTN, and DPP4, to predict cognitive recovery outcomes, and the administration of DPP4 inhibitors like gliptins to improve cognitive function during and after thrombectomy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If mechanical thrombectomy is performed to restore blood flow, then neurological function is improved, but cognitive impairment still occurs due to stroke injury

Engineering Contradiction:

Improveneurological functionVSAvoidcognitive impairment

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent performs thrombectomy to restore blood flow before cognitive impairment fully develops, and administers anti-inflammatory medications during the procedure to preemptively reduce inflammation-related cognitive damage. This preliminary action addresses the contradiction by preventing the harmful cognitive effects before they fully manifest.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent introduces anti-inflammatory medications as an intermediary substance that mediates between the thrombectomy procedure and cognitive outcomes. These medications reduce inflammation in the brain, thereby preventing the harmful cognitive effects of stroke while maintaining the beneficial neurological recovery from restored blood flow.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Device complexity

If no predictive tools are available, then all stroke patients receive standard treatment, but cognitive impairment risk cannot be identified early

Engineering Contradiction:

Improvetreatment protocolVSAvoidearly detection time

Core Design Contradiction:

Device complexityVSLoss of time

Solution Approach 1:

The patent performs thrombectomy to restore blood flow before cognitive impairment fully develops, and administers anti-inflammatory medications during the procedure to preemptively reduce inflammation-related cognitive damage. This preliminary action addresses the contradiction by preventing the harmful cognitive effects before they fully manifest.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent uses cognitive assessment tools to provide feedback on patient cognitive status, allowing clinicians to identify patients at risk for cognitive impairment and adjust treatment accordingly. This feedback mechanism enables early detection and targeted intervention without requiring complex customized treatment protocols for all patients.

Inventive Principle:

Principle #23Feedback

3Reliability

If disease-modifying treatments are not available for VCID, then cognitive impairment cannot be prevented, but early detection can focus medical attention and increase rehabilitation intensity

Engineering Contradiction:

Improvecognitive recoveryVSAvoidtreatment availability

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent performs thrombectomy to restore blood flow before cognitive impairment fully develops, and administers anti-inflammatory medications during the procedure to preemptively reduce inflammation-related cognitive damage. This preliminary action addresses the contradiction by preventing the harmful cognitive effects before they fully manifest.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent changes the parameter of rehabilitation intensity based on detected cognitive impairment risk. Patients identified as high-risk receive increased rehabilitation intensity, optimizing cognitive recovery outcomes without requiring disease-modifying treatments. This parameter adjustment makes effective treatment available through resource allocation rather than pharmaceutical development.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for early identification of cognitive impairment risk and administration of DPP4 inhibitors to enhance cognitive recovery in stroke patients, potentially reducing long-term cognitive disabilities and improving functional outcomes.

Implementation Method 1

administration of DPP4 inhibitors like gliptins to improve cognitive function

Methodology Applied

Scientific EffectEnzyme inhibition: Enzyme

Data Source

PatentUS20240036062A1Identifying risk of and treating stroke-induced cognitive impairment following thrombectomy

Publication Date: 2024.02.01 UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

AI summary

Tools for identifying risk of and for treating vascular contributions to cognitive impairment and dementia (VCID) and stroke-induced cognitive impairment in a subject are provided and include a method and a device that involve detecting target proteins in systemic blood sample from the subject.