DPPX Epitope Polypeptide Autoimmune Encephalitis Detection
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Solution Overview
Problem
Current diagnostic methods fail to effectively identify autoimmune encephalitis of unknown etiology, leading to undiagnosed cases and inappropriate management.
Innovation Solution
A polypeptide or protein comprising at least one epitope derived from DPPX, a novel autoantigen, is used for the detection of autoimmune encephalitis, along with associated nucleic acids, vectors, cells, and test kits to facilitate accurate diagnosis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional diagnostic methods are used for encephalitis, then general encephalitis detection is possible, but autoimmune encephalitis cannot be specifically identified
Solution Approach 1:
The invention segments the diagnostic approach by introducing a specific polypeptide comprising epitopes from DPPX, LGI1, and CASPR2 antigens. This segmented approach allows detection of autoimmune encephalitis specifically, distinguishing it from other encephalitis forms through targeted antibody detection against these identified autoantigens.
2Reliability
If autoimmune encephalitis remains undiagnosed, then general medical management continues, but appropriate immunotherapy cannot be administered
Solution Approach 1:
The invention performs preliminary action by pre-identifying and preparing diagnostic reagents (polypeptides with specific epitopes from DPPX, LGI1, and CASPR2) before clinical need arises. This allows immediate and accurate diagnosis when autoimmune encephalitis is suspected, enabling timely administration of appropriate immunotherapy without diagnostic delays.
3Measurement precision
If novel autoantigens DPPX, LGI1, and CASPR2 are identified and used for detection, then autoimmune encephalitis can be specifically diagnosed, but diagnostic complexity increases
Solution Approach 1:
The invention merges multiple epitope-specific polypeptides (from DPPX, LGI1, and CASPR2 antigens) into a comprehensive diagnostic system. This combined approach detects multiple autoimmune encephalitis types simultaneously, improving diagnostic accuracy while managing complexity through an integrated test kit format that presents a unified diagnostic solution.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the identification of autoimmune encephalitis, distinguishing it from other forms of encephalitis or diseases, and allows for targeted immunotherapy and intensive care support, improving patient outcomes.
Implementation Method 1
a polypeptide or protein comprising at least one epitope derived from DPPX, a novel autoantigen for detection of autoimmune disorder
Data Source
Figure 1A~1C
Figure 2A
Figure 2B~2BC
AI summary
The present invention relates to a polypeptide or protein for use in a method of diagnosis or treatment of an autoimmune disease in a subject, characterized in that said polypeptide or protein comprises one or more epitopes derived from the protein DPPX. Further, the invention relates to a nucleic acid or vector encoding such polypeptide, to a cell comprising such a vector, to an in vitro diagnostic method and test kit involving such polypeptide, to a pharmaceutical composition comprising such polypeptide, to a medical device coated with such polypeptide or pharmaceutical composition and to methods for treating an autoimmune disease in a subject.