Dragon Fruit Extracellular Vesicles for Antioxidant Fibroblast Support

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Solution Overview

Problem

There is a need for a novel ingredient derived from natural resources to improve conditions such as sagging skin, as existing solutions may not effectively address these issues.

Innovation Solution

The use of extracellular vesicles derived from dragon fruit, which exhibit antioxidant capacity and promote collagen and elastin production in fibroblasts.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing ingredients are used to improve skin conditions, then safety is maintained, but effectiveness in addressing sagging skin and related conditions is insufficient

Engineering Contradiction:
ImproveeffectivenessVSAvoidnovelty
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent extracts extracellular vesicles from dragon fruit as the active ingredient, isolating the specific component responsible for antioxidant activity and fibroblast promotion. This extraction principle resolves the contradiction by taking out the effective element from the whole fruit to create a targeted, effective ingredient that addresses sagging skin conditions better than existing ingredients.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the parameter of ingredient source from conventional ingredients to extracellular vesicles derived from dragon fruit. This parameter change introduces a novel ingredient with demonstrated antioxidant capacity and ability to promote collagen and elastin production, thereby improving effectiveness while maintaining safety through natural origin.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If natural resources are used as ingredients, then safety is improved, but the ability to effectively promote collagen and elastin production is insufficient

Engineering Contradiction:
ImprovesafetyVSAvoidcollagen and elastin production promotion
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The extracellular vesicles from dragon fruit naturally possess antioxidant capacity and fibroblast-promoting properties without requiring modification. This self-service principle resolves the contradiction by utilizing the inherent capabilities of the natural ingredient to effectively promote collagen and elastin production while maintaining safety through its natural origin.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent utilizes extracellular vesicles that contain multiple bioactive components working synergistically. This composite material approach combines antioxidants and fibroblast-promoting factors in a single natural extract, achieving both safety through natural origin and effectiveness in promoting collagen and elastin production.

Inventive Principle:
Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Extracellular vesicles from dragon fruit prevent oxidation and enhance collagen and elastin production, thereby improving skin conditions like sagging, wrinkles, and skin texture.

Implementation Method 1

extracellular vesicles derived from a dragon fruit have antioxidant capacity

Methodology Applied
Scientific EffectAntioxidant: Oxidation

Implementation Method 2

can also promote the expression of genes involved in the production of collagen and elastin in fibroblasts

Methodology Applied
Scientific EffectGene expression:

Data Source

PatentEP4582148A1Antioxidant and fibroblast promoter
Publication Date: 2025.07.09 ASFREYA INC
  • EP4582148A1 patent drawingFigure 1~2
  • EP4582148A1 patent drawingFigure 3~4
  • EP4582148A1 patent drawingFigure 5

AI summary

An object of the present invention is to provide a novel ingredient for improving various conditions in living organisms, such as sagging skin. An antioxidant of the present invention is characterized by containing extracellular vesicles derived from a dragon fruit. A fibroblast promoter of the present invention is characterized by containing extracellular vesicles derived from a dragon fruit. The dragon fruit is, for example, a red-fleshed dragon fruit.