Dried Probiotic Fermentation Broth for Feed Additives
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Solution Overview
Problem
Fermentation broths from probiotic microorganisms are typically discarded after microorganism separation, with limited utilization of the residual broth, and existing methods do not effectively preserve the enzymatic and antimicrobial activities necessary for use as feed additives.
Innovation Solution
Drying the residual fermentation broth after removing at least 20% of the microorganisms, using methods like freeze-drying or spray drying, to create a stable product that can be mixed with other feed additives, enhancing proteolytic, antimicrobial, and prebiotic activities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If the fermentation broth is dried to improve handling and application, then the ease of operation is improved, but the enzymatic and antimicrobial activities may be damaged
Solution Approach 1:
The patent applies parameter changes by controlling drying temperature and using protective agents during the drying process. The drying is performed at temperatures not exceeding 60°C, and protective agents such as sugars, polyols, and amino acids are added before drying to maintain the stability of enzymes and antimicrobial substances, thus resolving the contradiction between ease of handling and preservation of biological activities.
Solution Approach 2:
The patent implements beforehand cushioning by adding protective agents (sugars, polyols, amino acids, proteins) to the fermentation broth before the drying process. These agents form a protective matrix that cushions the enzymatic and antimicrobial substances against thermal and mechanical stress during drying, ensuring their activities are preserved while still achieving easy handling of the dried product.
2Reliability
If microorganisms are completely removed from the fermentation broth to improve purity, then the reliability is improved, but the loss of substance increases due to discarding the broth
Solution Approach 1:
The patent applies discarding and recovering by separating a portion of microorganisms (at least 20%) from the fermentation broth and then drying the remaining broth to recover the active substances (enzymes, antimicrobial compounds, metabolites) that would otherwise be discarded. This allows the broth to be reused as a feed additive, reducing substance loss while maintaining acceptable purity levels.
Solution Approach 2:
The patent implements universality by creating a multi-functional product from the fermentation broth that contains both residual microorganisms and active substances. The dried broth serves multiple functions: it provides probiotic microorganisms, enzymatic activity, antimicrobial protection, and prebiotic effects, thereby maximizing the utilization of the fermentation broth without requiring complete removal of microorganisms.
3Productivity
If the fermentation broth is used as feed additive to improve animal health, then the productivity is improved, but the complexity of the feed composition increases
Solution Approach 1:
The patent applies merging by combining multiple beneficial components (probiotic microorganisms, enzymes, antimicrobial substances, metabolites, and prebiotics) into a single integrated product - the dried fermentation broth. This unified product can be directly added to feed formulations, improving animal health and productivity while actually simplifying the overall feed composition by replacing multiple separate additives with one comprehensive solution.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dried fermentation broth maintains active substances' effectiveness, allowing for the production of feed products with superior characteristics, including improved proteolytic and antimicrobial activities, and reduced antinutritional factors, thus enhancing animal health and feed conversion rates.
Implementation Method 1
Drying of the fermentation broth is preferably carried out by freeze-drying, spray drying, vacuum drying, tray drying, drum drying, fluidized bed drying or spray granulation of the fermentation broth
Implementation Method 2
For spray drying the fermentation broth, fine droplets of the broth, atomized by spraying through a heated nozzle, are sprayed into a drying chamber against hot air
Implementation Method 3
Separation of the microorganisms from the fermentation broth may be carried out in particular by centrifugation, flotation, filtration, particularly ultrafiltration or microfiltration and/or decanting
Implementation Method 4
Separation of the microorganisms from the fermentation broth may be carried out in particular by centrifugation, flotation, filtration, particularly ultrafiltration or microfiltration and/or decanting
Implementation Method 5
Concentration of the fermentation broth may be carried out in particular by solvent evaporation. Solvent evaporation is preferably carried out, if applied, using a rotary evaporator, a thin film evaporator or a falling-film evaporator
Data Source
AI summary
SummaryAccording to the invention it was found out that fermentation broths of probiotic microorganisms show beneficial characteristics which make them suitable as feed additives as well as means for improving the properties of other feed additives.