Drive Screw Device Stabilizes Pressure in Capillary Electrophoresis

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Solution Overview

Problem

Existing capillary electrophoresis devices face challenges in stabilizing pressure during filling with a phoretic medium, leading to variations in liquid delivery, which affects processing capability and increases running costs.

Innovation Solution

A drive screw device with a drive unit, slider, and external load is used to stabilize pressure by applying a rotational load to the drive screw, reducing frictional fluctuations and maintaining consistent liquid delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If high pressure is applied to fill the capillary with fluid polymer, then filling time is reduced and processing capability is improved, but pressure variation and liquid delivery inconsistency occur

Engineering Contradiction:
Improveprocessing capabilityVSAvoidliquid delivery consistency
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The invention changes the physical state of the polymer from fluid to gel (crosslinked network), fundamentally altering the material properties. This allows the polymer to be delivered at low pressure while maintaining consistent flow characteristics, eliminating the pressure variation problems associated with high-viscosity fluid polymers

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The gel polymer is pre-crosslinked to form a stable network structure before delivery. This preliminary structural transformation cushions against pressure fluctuations during delivery, ensuring consistent flow rates and eliminating the need for high-pressure pumping while maintaining productivity

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

2Productivity

If fluid polymer is used instead of crosslinked gel, then productivity and performance stability are improved, but high pressure is required for filling which increases device complexity

Engineering Contradiction:
Improveperformance stabilityVSAvoidpump mechanism complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The invention transforms the polymer from a fluid state requiring high-pressure pumping to a gel state that can be delivered at low pressure. This parameter change (fluid → gel) eliminates the need for complex high-pressure pump mechanisms while maintaining the productivity and performance stability benefits of fluid polymers

Inventive Principle:
Principle #35Parameter changes

3Reliability

If polymer filling is performed at each measurement to prevent performance variation, then performance stability is improved, but time consumption increases

Engineering Contradiction:
Improveperformance stabilityVSAvoidfilling time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The gel polymer's pre-formed crosslinked network structure acts as a cushion that prevents performance variation during delivery. This allows continuous operation without repeated filling, as the gel maintains consistent flow characteristics throughout use, eliminating the time loss associated with frequent refilling while preserving performance stability

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach stabilizes pressure during capillary filling, reduces liquid delivery variations, and enables efficient, high-pressure delivery of the phoretic medium, enhancing processing capability and reducing operational costs.

Implementation Method 1

a drive screw; a drive unit which causes the drive screw to rotate; and a slider which moves along the drive screw by means of the rotation of the drive screw

Methodology Applied
Scientific EffectScrew mechanism: Screw

Implementation Method 2

an external load which is provided on the drive screw and applies a rotational load to the drive screw

Methodology Applied
Scientific EffectFriction: Friction

Data Source

PatentUS11029281B2Drive screw device, liquid delivery mechanism, and liquid delivery method
Publication Date: 2021.06.08 HITACHI HIGH TECH CORP
  • US11029281B2 patent drawing
  • US11029281B2 patent drawing
  • US11029281B2 patent drawing

AI summary

This drive screw device is provided with: a drive screw; a drive unit which causes the drive screw to rotate; a slider which moves along the drive screw by means of the rotation of the drive screw; and an external load which is provided on the drive screw and applies a rotational load to the drive screw. By this means it is possible to provide a drive screw device with which there is little pressure variation even if a frictional force varies.