Drop Preparation Device with Deformable Cap for Pressure Regulation
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Solution Overview
Problem
Current digital PCR drop preparation technologies face issues with pressure fluctuation, leading to poor drop quality and uneven drop sizes due to inadequate pressure regulation.
Innovation Solution
A drop preparation device with a cavity, chip, pressure detection unit, temperature control module, and a deformable perforated cap, which adjusts pressure and temperature to maintain a preset pressure range, ensuring uniform drop production by controlling the pressing assembly and vent hole volume.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If pressure is regulated to control drop production, then drop production is enabled, but pressure fluctuation occurs leading to poor drop quality and uneven size
Solution Approach 1:
The patent employs a feedback control mechanism where a pressure sensor detects pressure values in real-time, and a controller adjusts the pressing force based on detected pressure deviations to maintain stable pressure and uniform drop production
Solution Approach 2:
The pressing assembly is designed to dynamically adjust pressing force in response to pressure fluctuations, transitioning from static pressure application to active pressure regulation to ensure consistent drop quality
2Manufacturing precision
If pressing force is increased to improve drop production control, then drop formation is enhanced, but pressure fluctuation worsens
Solution Approach 1:
The pressure sensor and controller work together to provide feedback control, detecting pressure changes and adjusting pressing force accordingly to maintain optimal pressure levels without excessive fluctuation
Solution Approach 2:
The system dynamically changes pressing force parameters based on real-time pressure detection, adjusting the magnitude and duration of pressing to optimize drop production while minimizing pressure instability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution improves drop quality and uniformity by dynamically adjusting pressure and temperature, allowing for quick and stable production of uniform drops, addressing the issue of pressure fluctuation and enhancing the reliability of drop production.
Implementation Method 1
a pressure detection unit... configured for detecting a pressure data in the cavity
Implementation Method 2
the temperature control module is configured for adjusting a temperature value in the chip
Implementation Method 3
the perforated cap is configured to be elastically deformed along the up-down direction under a pressing force to change a volume of the vent hole
Implementation Method 4
a positive pressure is applied into the chip through the sample inlet to form a pressure difference in the chip
Data Source
AI summary
The present application discloses drop preparation device and drop preparation method and relates to the technical field of biochip. In the drop preparation device, the chip, the temperature control module and the pressure detection unit are provided in the cavity, the temperature control module is configured for adjusting a temperature value in the chip, and the pressure detection unit is configured for detecting a pressure data in the cavity; two chip ports, that is, a sample inlet and an oil inlet are provided at the top of the chip; the perforated cap has a vent hole and is elastically deformed to change a volume of the vent hole. When the perforated cap is directly connected to the oil inlet, the pressing assembly is lifted or lowered to open or cover the vent hole. When the pressing assembly covers the oil inlet, a pressure difference is formed in the chip.