Drug Delivery System Back Pressure Sensing
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Solution Overview
Problem
Parenteral drug delivery systems face challenges in ensuring precise delivery of drugs due to tissue back pressure, which can lead to incomplete dosing and leakage, especially with higher injection rates and viscous formulations, compromising drug efficacy and increasing the risk of adverse side effects.
Innovation Solution
A drug delivery system equipped with a pressure sensor to detect tissue back pressure during and after injection, allowing for adjusted operation to prevent leakage, including automatic actuation and retraction of the administration member, ensuring complete drug delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If higher injection rates are used to improve productivity, then injection speed increases, but tissue back pressure increases causing incomplete delivery and leakage
Solution Approach 1:
The pressure sensor provides real-time feedback on tissue back pressure during injection. The system monitors pressure levels and automatically adjusts the drive assembly operation or extends dwell time to ensure complete drug delivery even at higher injection rates, preventing both leakage and incomplete delivery.
2Productivity
If faster injection is performed to reduce treatment time, then productivity improves, but drug leakage increases compromising dosing precision
Solution Approach 1:
The pressure sensor monitors tissue back pressure throughout the injection process and during dwell time. This feedback enables the system to detect when injection is complete and when pressure has equalized, ensuring precise dosing delivery even when using faster injection rates to reduce overall treatment time.
Solution Approach 2:
The system dynamically adjusts the injection profile based on real-time pressure feedback. The drive assembly can modify injection rate, pause for dwell time, and extend or reduce retention time based on pressure equalization, allowing optimized dosing precision with reduced treatment time.
3Reliability
If pressure monitoring is added to detect tissue back pressure, then delivery reliability improves, but device complexity increases
Solution Approach 1:
The pressure sensor replaces complex mechanical pressure indication systems with an electronic sensing and signaling system. This provides more reliable and precise pressure detection while integrating seamlessly with the electronic drive assembly control, overall reducing system complexity compared to pure mechanical approaches.
4Reliability
If dwell time is extended to allow pressure equalization and prevent leakage, then delivery reliability improves, but treatment time increases
Solution Approach 1:
The pressure sensor provides real-time feedback during the dwell time period, monitoring when tissue back pressure has equalized with reservoir pressure. This allows the system to determine the precise moment when the administration member can be safely removed without leakage, minimizing dwell time and treatment duration while ensuring complete drug delivery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively reduces the risk of drug leakage and ensures precise dosing by monitoring tissue back pressure, maintaining the integrity of the drug delivery process and enhancing patient safety.
Implementation Method 1
a pressure sensor configured to detect tissue back pressure during use of the drug delivery system
Data Source
AI summary
Systems and methods for injecting a drug and detecting tissue induced back pressure are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, an administration member connected or connectable in fluid communication with the reservoir, a drive assembly, and a pressure sensor. The administration member may be configured for insertion into and subsequently retraction from a patient. The drive assembly may be configured to urge the drug from the reservoir to deliver a dose of the drug to the patient via the administration member. The pressure sensor may be configured to detect tissue back pressure during use of the drug delivery system, including after dose completion and prior to retraction of the administration member. The drug delivery system may be controlled in a manner that accounts for the tissue back pressure measurement.