Drug Delivery Device with Rotating Carrier and Insert
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Solution Overview
Problem
Current drug delivery devices face challenges in delivering low permeable and low water soluble active drug substances through the gastrointestinal tract due to stability issues and limited absorption, particularly due to the gastrointestinal wall barrier, pre-systemic metabolism, size, charge, and water solubility, leading to limited success in oral administration.
Innovation Solution
A drug delivery device with a central axis, comprising a carrier and an insert, featuring a rotating mechanism that allows for attachment to the gastrointestinal tissue, enabling improved stability and absorption by facilitating interaction with the mucous membranes and allowing for reusable and modular design.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If oral administration is used for low permeable and low water soluble active drug substances, then patient acceptance and compliance are improved, but stability and absorption are worsened due to gastrointestinal barriers and pre-systemic metabolism
Solution Approach 1:
The device is divided into separate functional components: a carrier that protects the drug substance during gastrointestinal passage and an insert that delivers the drug directly to the absorption site. This segmentation allows the drug to bypass the harmful gastrointestinal environment while maintaining oral administration benefits.
Solution Approach 2:
The carrier acts as an intermediary protective structure that shields the low permeable and low water soluble active drug substance from degradation in the gastrointestinal tract. The carrier enables oral administration by mediating between the drug's instability and the gastrointestinal environment's harsh conditions.
2Productivity
If the drug delivery device is designed for reusable components and modular assembly, then waste is reduced and manufacturing efficiency is improved, but device complexity increases
Solution Approach 1:
The drug delivery device is segmented into a reusable carrier and replaceable inserts, allowing independent manufacturing and assembly of components. This modular design enables efficient production of each component separately while reducing overall waste by reusing the carrier structure.
Solution Approach 2:
The carrier is designed as a universal component that can accommodate multiple different inserts containing various drug substances. This multi-functionality allows a single carrier design to serve multiple drug delivery purposes, improving manufacturing efficiency and reducing the need for multiple specialized device designs.
Data Source
AI summary
A drug delivery device having an axis, the drug delivery device comprising a carrier and an insert, the carrier comprising a first body part having a first recess, a first attachment part attached to the first body part and having a first distal end, a second body part having a second recess an actuator mechanism configured to rotate at least one of the first body part or the second body part with respect to one another about the axis, and an insert configured to be inserted and fixed in the second recess, the insert comprising a second attachment part and an insert body with an insert recess, the second attachment part having a second distal end.